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Old Disease and New Challenges: Major Obstacles of Current Strategies in the Prevention of Pertussis
CONTEXT: Universal immunization against Bordetella pertussis has partially controlled the burden of the disease and its transmission. However, according to recent data, the epidemiology of this vaccine-preventable disease has changed. Now, younger infants, adolescents, and adults are at greater risk...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047029/ https://www.ncbi.nlm.nih.gov/pubmed/27729960 http://dx.doi.org/10.5812/ijp.5514 |
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author | Sedighi, Iraj Karimi, Abdollah Amanati, Ali |
author_facet | Sedighi, Iraj Karimi, Abdollah Amanati, Ali |
author_sort | Sedighi, Iraj |
collection | PubMed |
description | CONTEXT: Universal immunization against Bordetella pertussis has partially controlled the burden of the disease and its transmission. However, according to recent data, the epidemiology of this vaccine-preventable disease has changed. Now, younger infants, adolescents, and adults are at greater risk of infection. This article has studied the interaction between the various factors involved in the changing epidemiology of pertussis and the major obstacles faced by the current strategies in its prevention. EVIDENCE ACQUISITION: In this narrative review, the most recently published sources of information on pertussis control measures, consisting of textbooks and articles, have been reviewed. We focused on the more recent data about the changing epidemiology or pertussis in Scopus through the use of the MeSH-term words [pertussis] or [whooping cough] and [epidemiology] or [outbreak] or [resurgence], but our search was not restricted to this particular strategy; we also tried to find all of the most recent available data in the general field through other means. RESULTS: Primary and booster doses of the pertussis vaccine seem to partially control transmission of the disease, but despite the different preventive strategies available, pertussis continues to cause mortality and morbidity among high-risk groups. CONCLUSIONS: Adding booster doses of acellular pertussis vaccine to the current national immunization practices with whole-cell vaccines for young adults and pregnant women seems to be a good option for controlling mortality and morbidity among high-risk groups such as very young infants. |
format | Online Article Text |
id | pubmed-5047029 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-50470292016-10-11 Old Disease and New Challenges: Major Obstacles of Current Strategies in the Prevention of Pertussis Sedighi, Iraj Karimi, Abdollah Amanati, Ali Iran J Pediatr Review Article CONTEXT: Universal immunization against Bordetella pertussis has partially controlled the burden of the disease and its transmission. However, according to recent data, the epidemiology of this vaccine-preventable disease has changed. Now, younger infants, adolescents, and adults are at greater risk of infection. This article has studied the interaction between the various factors involved in the changing epidemiology of pertussis and the major obstacles faced by the current strategies in its prevention. EVIDENCE ACQUISITION: In this narrative review, the most recently published sources of information on pertussis control measures, consisting of textbooks and articles, have been reviewed. We focused on the more recent data about the changing epidemiology or pertussis in Scopus through the use of the MeSH-term words [pertussis] or [whooping cough] and [epidemiology] or [outbreak] or [resurgence], but our search was not restricted to this particular strategy; we also tried to find all of the most recent available data in the general field through other means. RESULTS: Primary and booster doses of the pertussis vaccine seem to partially control transmission of the disease, but despite the different preventive strategies available, pertussis continues to cause mortality and morbidity among high-risk groups. CONCLUSIONS: Adding booster doses of acellular pertussis vaccine to the current national immunization practices with whole-cell vaccines for young adults and pregnant women seems to be a good option for controlling mortality and morbidity among high-risk groups such as very young infants. Kowsar 2016-06-12 /pmc/articles/PMC5047029/ /pubmed/27729960 http://dx.doi.org/10.5812/ijp.5514 Text en Copyright © 2016, Growth & Development Research Center http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. |
spellingShingle | Review Article Sedighi, Iraj Karimi, Abdollah Amanati, Ali Old Disease and New Challenges: Major Obstacles of Current Strategies in the Prevention of Pertussis |
title | Old Disease and New Challenges: Major Obstacles of Current Strategies in the Prevention of Pertussis |
title_full | Old Disease and New Challenges: Major Obstacles of Current Strategies in the Prevention of Pertussis |
title_fullStr | Old Disease and New Challenges: Major Obstacles of Current Strategies in the Prevention of Pertussis |
title_full_unstemmed | Old Disease and New Challenges: Major Obstacles of Current Strategies in the Prevention of Pertussis |
title_short | Old Disease and New Challenges: Major Obstacles of Current Strategies in the Prevention of Pertussis |
title_sort | old disease and new challenges: major obstacles of current strategies in the prevention of pertussis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047029/ https://www.ncbi.nlm.nih.gov/pubmed/27729960 http://dx.doi.org/10.5812/ijp.5514 |
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