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Formal modeling and analysis of the hexosamine biosynthetic pathway: role of O-linked N-acetylglucosamine transferase in oncogenesis and cancer progression

The alteration of glucose metabolism, through increased uptake of glucose and glutamine addiction, is essential to cancer cell growth and invasion. Increased flux of glucose through the Hexosamine Biosynthetic Pathway (HBP) drives increased cellular O-GlcNAcylation (hyper-O-GlcNAcylation) and contri...

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Detalles Bibliográficos
Autores principales:	Saeed, Muhammad Tariq, Ahmad, Jamil, Kanwal, Shahzina, Holowatyj, Andreana N., Sheikh, Iftikhar A., Zafar Paracha, Rehan, Shafi, Aamir, Siddiqa, Amnah, Bibi, Zurah, Khan, Mukaram, Ali, Amjad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2016
Materias:	Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047222/ https://www.ncbi.nlm.nih.gov/pubmed/27703839 http://dx.doi.org/10.7717/peerj.2348

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