Cargando…

Point-of-Care Viral Load Testing for Sub-Saharan Africa: Informing a Target Product Profile

Point-of-care viral load tests are being developed to monitor patients on antiretroviral therapy (ART) in sub-Saharan Africa. Test design involves trade-offs between test attributes, including accuracy, complexity, robustness, and cost. We used a model of the human immunodeficiency virus epidemic an...

Descripción completa

Detalles Bibliográficos
Autores principales: Phillips, Andrew N., Cambiano, Valentina, Nakagawa, Fumiyo, Ford, Deborah, Apollo, Tsitsi, Murungu, Joseph, Rousseau, Christine, Garnett, Geoff, Ehrenkranz, Peter, Bansi-Matharu, Loveleen, Vojnov, Lara, Katz, Zachary, Peeling, Rosanna, Revill, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047406/
https://www.ncbi.nlm.nih.gov/pubmed/27704016
http://dx.doi.org/10.1093/ofid/ofw161
Descripción
Sumario:Point-of-care viral load tests are being developed to monitor patients on antiretroviral therapy (ART) in sub-Saharan Africa. Test design involves trade-offs between test attributes, including accuracy, complexity, robustness, and cost. We used a model of the human immunodeficiency virus epidemic and ART program in Zimbabwe and found that the attributes of a viral load testing approach that are most influential for cost effectiveness are avoidance of a high proportion of failed tests or results not received, use of an approach that best facilitates retention on ART, and the ability to facilitate greater use of differentiated care, including through expanding coverage of testing availability.