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Point-of-Care Viral Load Testing for Sub-Saharan Africa: Informing a Target Product Profile

Point-of-care viral load tests are being developed to monitor patients on antiretroviral therapy (ART) in sub-Saharan Africa. Test design involves trade-offs between test attributes, including accuracy, complexity, robustness, and cost. We used a model of the human immunodeficiency virus epidemic an...

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Autores principales: Phillips, Andrew N., Cambiano, Valentina, Nakagawa, Fumiyo, Ford, Deborah, Apollo, Tsitsi, Murungu, Joseph, Rousseau, Christine, Garnett, Geoff, Ehrenkranz, Peter, Bansi-Matharu, Loveleen, Vojnov, Lara, Katz, Zachary, Peeling, Rosanna, Revill, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047406/
https://www.ncbi.nlm.nih.gov/pubmed/27704016
http://dx.doi.org/10.1093/ofid/ofw161
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author Phillips, Andrew N.
Cambiano, Valentina
Nakagawa, Fumiyo
Ford, Deborah
Apollo, Tsitsi
Murungu, Joseph
Rousseau, Christine
Garnett, Geoff
Ehrenkranz, Peter
Bansi-Matharu, Loveleen
Vojnov, Lara
Katz, Zachary
Peeling, Rosanna
Revill, Paul
author_facet Phillips, Andrew N.
Cambiano, Valentina
Nakagawa, Fumiyo
Ford, Deborah
Apollo, Tsitsi
Murungu, Joseph
Rousseau, Christine
Garnett, Geoff
Ehrenkranz, Peter
Bansi-Matharu, Loveleen
Vojnov, Lara
Katz, Zachary
Peeling, Rosanna
Revill, Paul
author_sort Phillips, Andrew N.
collection PubMed
description Point-of-care viral load tests are being developed to monitor patients on antiretroviral therapy (ART) in sub-Saharan Africa. Test design involves trade-offs between test attributes, including accuracy, complexity, robustness, and cost. We used a model of the human immunodeficiency virus epidemic and ART program in Zimbabwe and found that the attributes of a viral load testing approach that are most influential for cost effectiveness are avoidance of a high proportion of failed tests or results not received, use of an approach that best facilitates retention on ART, and the ability to facilitate greater use of differentiated care, including through expanding coverage of testing availability.
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spelling pubmed-50474062016-10-04 Point-of-Care Viral Load Testing for Sub-Saharan Africa: Informing a Target Product Profile Phillips, Andrew N. Cambiano, Valentina Nakagawa, Fumiyo Ford, Deborah Apollo, Tsitsi Murungu, Joseph Rousseau, Christine Garnett, Geoff Ehrenkranz, Peter Bansi-Matharu, Loveleen Vojnov, Lara Katz, Zachary Peeling, Rosanna Revill, Paul Open Forum Infect Dis Major Articles Point-of-care viral load tests are being developed to monitor patients on antiretroviral therapy (ART) in sub-Saharan Africa. Test design involves trade-offs between test attributes, including accuracy, complexity, robustness, and cost. We used a model of the human immunodeficiency virus epidemic and ART program in Zimbabwe and found that the attributes of a viral load testing approach that are most influential for cost effectiveness are avoidance of a high proportion of failed tests or results not received, use of an approach that best facilitates retention on ART, and the ability to facilitate greater use of differentiated care, including through expanding coverage of testing availability. Oxford University Press 2016-07-29 /pmc/articles/PMC5047406/ /pubmed/27704016 http://dx.doi.org/10.1093/ofid/ofw161 Text en © The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Major Articles
Phillips, Andrew N.
Cambiano, Valentina
Nakagawa, Fumiyo
Ford, Deborah
Apollo, Tsitsi
Murungu, Joseph
Rousseau, Christine
Garnett, Geoff
Ehrenkranz, Peter
Bansi-Matharu, Loveleen
Vojnov, Lara
Katz, Zachary
Peeling, Rosanna
Revill, Paul
Point-of-Care Viral Load Testing for Sub-Saharan Africa: Informing a Target Product Profile
title Point-of-Care Viral Load Testing for Sub-Saharan Africa: Informing a Target Product Profile
title_full Point-of-Care Viral Load Testing for Sub-Saharan Africa: Informing a Target Product Profile
title_fullStr Point-of-Care Viral Load Testing for Sub-Saharan Africa: Informing a Target Product Profile
title_full_unstemmed Point-of-Care Viral Load Testing for Sub-Saharan Africa: Informing a Target Product Profile
title_short Point-of-Care Viral Load Testing for Sub-Saharan Africa: Informing a Target Product Profile
title_sort point-of-care viral load testing for sub-saharan africa: informing a target product profile
topic Major Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047406/
https://www.ncbi.nlm.nih.gov/pubmed/27704016
http://dx.doi.org/10.1093/ofid/ofw161
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