Increase in Middle East Respiratory Syndrome-Coronavirus Cases in Saudi Arabia Linked to Hospital Outbreak With Continued Circulation of Recombinant Virus, July 1–August 31, 2015

During July–August 2015, the number of cases of Middle East respiratory syndrome (MERS) reported from Saudi Arabia increased dramatically. We reviewed the 143 confirmed cases from this period and classified each based upon likely transmission source. We found that the surge in cases resulted predomi...

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Autores principales: Assiri, Abdullah M., Biggs, Holly M., Abedi, Glen R., Lu, Xiaoyan, Bin Saeed, Abdulaziz, Abdalla, Osman, Mohammed, Mutaz, Al-Abdely, Hail M., Algarni, Homoud S., Alhakeem, Raafat F., Almasri, Malak M., Alsharef, Ali A., Nooh, Randa, Erdman, Dean D., Gerber, Susan I., Watson, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047409/
https://www.ncbi.nlm.nih.gov/pubmed/27704019
http://dx.doi.org/10.1093/ofid/ofw165
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author Assiri, Abdullah M.
Biggs, Holly M.
Abedi, Glen R.
Lu, Xiaoyan
Bin Saeed, Abdulaziz
Abdalla, Osman
Mohammed, Mutaz
Al-Abdely, Hail M.
Algarni, Homoud S.
Alhakeem, Raafat F.
Almasri, Malak M.
Alsharef, Ali A.
Nooh, Randa
Erdman, Dean D.
Gerber, Susan I.
Watson, John T.
author_facet Assiri, Abdullah M.
Biggs, Holly M.
Abedi, Glen R.
Lu, Xiaoyan
Bin Saeed, Abdulaziz
Abdalla, Osman
Mohammed, Mutaz
Al-Abdely, Hail M.
Algarni, Homoud S.
Alhakeem, Raafat F.
Almasri, Malak M.
Alsharef, Ali A.
Nooh, Randa
Erdman, Dean D.
Gerber, Susan I.
Watson, John T.
author_sort Assiri, Abdullah M.
collection PubMed
description During July–August 2015, the number of cases of Middle East respiratory syndrome (MERS) reported from Saudi Arabia increased dramatically. We reviewed the 143 confirmed cases from this period and classified each based upon likely transmission source. We found that the surge in cases resulted predominantly (90%) from secondary transmission largely attributable to an outbreak at a single healthcare facility in Riyadh. Genome sequencing of MERS coronavirus from 6 cases demonstrated continued circulation of the recently described recombinant virus. A single unique frameshift deletion in open reading frame 5 was detected in the viral sequence from 1 case.
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spelling pubmed-50474092016-10-04 Increase in Middle East Respiratory Syndrome-Coronavirus Cases in Saudi Arabia Linked to Hospital Outbreak With Continued Circulation of Recombinant Virus, July 1–August 31, 2015 Assiri, Abdullah M. Biggs, Holly M. Abedi, Glen R. Lu, Xiaoyan Bin Saeed, Abdulaziz Abdalla, Osman Mohammed, Mutaz Al-Abdely, Hail M. Algarni, Homoud S. Alhakeem, Raafat F. Almasri, Malak M. Alsharef, Ali A. Nooh, Randa Erdman, Dean D. Gerber, Susan I. Watson, John T. Open Forum Infect Dis Brief Reports During July–August 2015, the number of cases of Middle East respiratory syndrome (MERS) reported from Saudi Arabia increased dramatically. We reviewed the 143 confirmed cases from this period and classified each based upon likely transmission source. We found that the surge in cases resulted predominantly (90%) from secondary transmission largely attributable to an outbreak at a single healthcare facility in Riyadh. Genome sequencing of MERS coronavirus from 6 cases demonstrated continued circulation of the recently described recombinant virus. A single unique frameshift deletion in open reading frame 5 was detected in the viral sequence from 1 case. Oxford University Press 2016-08-03 /pmc/articles/PMC5047409/ /pubmed/27704019 http://dx.doi.org/10.1093/ofid/ofw165 Text en Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Assiri, Abdullah M.
Biggs, Holly M.
Abedi, Glen R.
Lu, Xiaoyan
Bin Saeed, Abdulaziz
Abdalla, Osman
Mohammed, Mutaz
Al-Abdely, Hail M.
Algarni, Homoud S.
Alhakeem, Raafat F.
Almasri, Malak M.
Alsharef, Ali A.
Nooh, Randa
Erdman, Dean D.
Gerber, Susan I.
Watson, John T.
Increase in Middle East Respiratory Syndrome-Coronavirus Cases in Saudi Arabia Linked to Hospital Outbreak With Continued Circulation of Recombinant Virus, July 1–August 31, 2015
title Increase in Middle East Respiratory Syndrome-Coronavirus Cases in Saudi Arabia Linked to Hospital Outbreak With Continued Circulation of Recombinant Virus, July 1–August 31, 2015
title_full Increase in Middle East Respiratory Syndrome-Coronavirus Cases in Saudi Arabia Linked to Hospital Outbreak With Continued Circulation of Recombinant Virus, July 1–August 31, 2015
title_fullStr Increase in Middle East Respiratory Syndrome-Coronavirus Cases in Saudi Arabia Linked to Hospital Outbreak With Continued Circulation of Recombinant Virus, July 1–August 31, 2015
title_full_unstemmed Increase in Middle East Respiratory Syndrome-Coronavirus Cases in Saudi Arabia Linked to Hospital Outbreak With Continued Circulation of Recombinant Virus, July 1–August 31, 2015
title_short Increase in Middle East Respiratory Syndrome-Coronavirus Cases in Saudi Arabia Linked to Hospital Outbreak With Continued Circulation of Recombinant Virus, July 1–August 31, 2015
title_sort increase in middle east respiratory syndrome-coronavirus cases in saudi arabia linked to hospital outbreak with continued circulation of recombinant virus, july 1–august 31, 2015
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047409/
https://www.ncbi.nlm.nih.gov/pubmed/27704019
http://dx.doi.org/10.1093/ofid/ofw165
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