Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing

We report the case of a 60-year-old man with septic shock due to Capnocytophaga canimorsus that was diagnosed in 24 hours by a novel whole-genome next-generation sequencing assay. This technology shows great promise in identifying fastidious pathogens, and, if validated, it has profound implications...

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Autores principales: Abril, Maria K., Barnett, Adam S., Wegermann, Kara, Fountain, Eric, Strand, Andrew, Heyman, Benjamin M., Blough, Britton A., Swaminathan, Aparna C., Sharma-Kuinkel, Batu, Ruffin, Felicia, Alexander, Barbara D., McCall, Chad M., Costa, Sylvia F., Arcasoy, Murat O., Hong, David K., Blauwkamp, Timothy A., Kertesz, Michael, Fowler, Vance G., Kraft, Bryan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047422/
https://www.ncbi.nlm.nih.gov/pubmed/27704003
http://dx.doi.org/10.1093/ofid/ofw144
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author Abril, Maria K.
Barnett, Adam S.
Wegermann, Kara
Fountain, Eric
Strand, Andrew
Heyman, Benjamin M.
Blough, Britton A.
Swaminathan, Aparna C.
Sharma-Kuinkel, Batu
Ruffin, Felicia
Alexander, Barbara D.
McCall, Chad M.
Costa, Sylvia F.
Arcasoy, Murat O.
Hong, David K.
Blauwkamp, Timothy A.
Kertesz, Michael
Fowler, Vance G.
Kraft, Bryan D.
author_facet Abril, Maria K.
Barnett, Adam S.
Wegermann, Kara
Fountain, Eric
Strand, Andrew
Heyman, Benjamin M.
Blough, Britton A.
Swaminathan, Aparna C.
Sharma-Kuinkel, Batu
Ruffin, Felicia
Alexander, Barbara D.
McCall, Chad M.
Costa, Sylvia F.
Arcasoy, Murat O.
Hong, David K.
Blauwkamp, Timothy A.
Kertesz, Michael
Fowler, Vance G.
Kraft, Bryan D.
author_sort Abril, Maria K.
collection PubMed
description We report the case of a 60-year-old man with septic shock due to Capnocytophaga canimorsus that was diagnosed in 24 hours by a novel whole-genome next-generation sequencing assay. This technology shows great promise in identifying fastidious pathogens, and, if validated, it has profound implications for infectious disease diagnosis.
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spelling pubmed-50474222016-10-04 Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing Abril, Maria K. Barnett, Adam S. Wegermann, Kara Fountain, Eric Strand, Andrew Heyman, Benjamin M. Blough, Britton A. Swaminathan, Aparna C. Sharma-Kuinkel, Batu Ruffin, Felicia Alexander, Barbara D. McCall, Chad M. Costa, Sylvia F. Arcasoy, Murat O. Hong, David K. Blauwkamp, Timothy A. Kertesz, Michael Fowler, Vance G. Kraft, Bryan D. Open Forum Infect Dis Brief Reports We report the case of a 60-year-old man with septic shock due to Capnocytophaga canimorsus that was diagnosed in 24 hours by a novel whole-genome next-generation sequencing assay. This technology shows great promise in identifying fastidious pathogens, and, if validated, it has profound implications for infectious disease diagnosis. Oxford University Press 2016-07-12 /pmc/articles/PMC5047422/ /pubmed/27704003 http://dx.doi.org/10.1093/ofid/ofw144 Text en © The Author 2016. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.
spellingShingle Brief Reports
Abril, Maria K.
Barnett, Adam S.
Wegermann, Kara
Fountain, Eric
Strand, Andrew
Heyman, Benjamin M.
Blough, Britton A.
Swaminathan, Aparna C.
Sharma-Kuinkel, Batu
Ruffin, Felicia
Alexander, Barbara D.
McCall, Chad M.
Costa, Sylvia F.
Arcasoy, Murat O.
Hong, David K.
Blauwkamp, Timothy A.
Kertesz, Michael
Fowler, Vance G.
Kraft, Bryan D.
Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing
title Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing
title_full Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing
title_fullStr Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing
title_full_unstemmed Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing
title_short Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing
title_sort diagnosis of capnocytophaga canimorsus sepsis by whole-genome next-generation sequencing
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047422/
https://www.ncbi.nlm.nih.gov/pubmed/27704003
http://dx.doi.org/10.1093/ofid/ofw144
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