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Differences in the Epidemiology of Childhood Infections with Avian Influenza A H7N9 and H5N1 Viruses
The difference between childhood infections with avian influenza viruses A(H5N1) and A(H7N9) remains an unresolved but critically important question. We compared the epidemiological characteristics of 244 H5N1 and 41 H7N9 childhood cases (<15 years old), as well as the childhood cluster cases of...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047462/ https://www.ncbi.nlm.nih.gov/pubmed/27695069 http://dx.doi.org/10.1371/journal.pone.0161925 |
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author | Sha, Jianping Dong, Wei Liu, Shelan Chen, Xiaowen Zhao, Na Luo, Mengyun Dong, Yuanyuan Zhang, Zhiruo |
author_facet | Sha, Jianping Dong, Wei Liu, Shelan Chen, Xiaowen Zhao, Na Luo, Mengyun Dong, Yuanyuan Zhang, Zhiruo |
author_sort | Sha, Jianping |
collection | PubMed |
description | The difference between childhood infections with avian influenza viruses A(H5N1) and A(H7N9) remains an unresolved but critically important question. We compared the epidemiological characteristics of 244 H5N1 and 41 H7N9 childhood cases (<15 years old), as well as the childhood cluster cases of the two viruses. Our findings revealed a higher proportion of H5N1 than H7N9 childhood infections (31.1% vs. 6.4%, p = 0.000). However, the two groups did not differ significantly in age (median age: 5.0 vs. 5.5 y, p = 0.0651). The proportion of clustered cases was significantly greater among children infected with H5N1 than among children infected with H7N9 [46.7% (71/152) vs. 23.6% (13/55), p = 0.005], and most of the childhood cases were identified as secondary cases [46.4% (45/97) vs. 33.3% (10/30), p = 0.000]. Mild status accounted for 79.49% and 22.66%, severe status for 17.95% and 2.34%, and fatal cases for 2.56% and 75.00% of the H7N9 and H5N1 childhood infection cases (all p<0.05), respectively. The fatality rates for the total, index and secondary childhood cluster cases were 52.86% (37/70), 88.5% (23/26) and 33.33% (15/45), respectively, in the H5N1 group, whereas no fatal H7N9 childhood cluster cases were identified. In conclusion, lower severity and greater transmission were found in the H7N9 childhood cases than in the H5N1 childhood cases. |
format | Online Article Text |
id | pubmed-5047462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-50474622016-10-27 Differences in the Epidemiology of Childhood Infections with Avian Influenza A H7N9 and H5N1 Viruses Sha, Jianping Dong, Wei Liu, Shelan Chen, Xiaowen Zhao, Na Luo, Mengyun Dong, Yuanyuan Zhang, Zhiruo PLoS One Research Article The difference between childhood infections with avian influenza viruses A(H5N1) and A(H7N9) remains an unresolved but critically important question. We compared the epidemiological characteristics of 244 H5N1 and 41 H7N9 childhood cases (<15 years old), as well as the childhood cluster cases of the two viruses. Our findings revealed a higher proportion of H5N1 than H7N9 childhood infections (31.1% vs. 6.4%, p = 0.000). However, the two groups did not differ significantly in age (median age: 5.0 vs. 5.5 y, p = 0.0651). The proportion of clustered cases was significantly greater among children infected with H5N1 than among children infected with H7N9 [46.7% (71/152) vs. 23.6% (13/55), p = 0.005], and most of the childhood cases were identified as secondary cases [46.4% (45/97) vs. 33.3% (10/30), p = 0.000]. Mild status accounted for 79.49% and 22.66%, severe status for 17.95% and 2.34%, and fatal cases for 2.56% and 75.00% of the H7N9 and H5N1 childhood infection cases (all p<0.05), respectively. The fatality rates for the total, index and secondary childhood cluster cases were 52.86% (37/70), 88.5% (23/26) and 33.33% (15/45), respectively, in the H5N1 group, whereas no fatal H7N9 childhood cluster cases were identified. In conclusion, lower severity and greater transmission were found in the H7N9 childhood cases than in the H5N1 childhood cases. Public Library of Science 2016-10-03 /pmc/articles/PMC5047462/ /pubmed/27695069 http://dx.doi.org/10.1371/journal.pone.0161925 Text en © 2016 Sha et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sha, Jianping Dong, Wei Liu, Shelan Chen, Xiaowen Zhao, Na Luo, Mengyun Dong, Yuanyuan Zhang, Zhiruo Differences in the Epidemiology of Childhood Infections with Avian Influenza A H7N9 and H5N1 Viruses |
title | Differences in the Epidemiology of Childhood Infections with Avian Influenza A H7N9 and H5N1 Viruses |
title_full | Differences in the Epidemiology of Childhood Infections with Avian Influenza A H7N9 and H5N1 Viruses |
title_fullStr | Differences in the Epidemiology of Childhood Infections with Avian Influenza A H7N9 and H5N1 Viruses |
title_full_unstemmed | Differences in the Epidemiology of Childhood Infections with Avian Influenza A H7N9 and H5N1 Viruses |
title_short | Differences in the Epidemiology of Childhood Infections with Avian Influenza A H7N9 and H5N1 Viruses |
title_sort | differences in the epidemiology of childhood infections with avian influenza a h7n9 and h5n1 viruses |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047462/ https://www.ncbi.nlm.nih.gov/pubmed/27695069 http://dx.doi.org/10.1371/journal.pone.0161925 |
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