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Studying Closed Hydrodynamic Models of “In Vivo” DNA Perfusion in Pig Liver for Gene Therapy Translation to Humans

INTRODUCTION: Expressing exogenous genes after naked DNA delivery into hepatocytes might achieve sustained and high expression of human proteins. Tail vein DNA injection is an efficient procedure for gene transfer in murine liver. Hydrodynamic procedures in large animals require organ targeting, and...

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Detalles Bibliográficos
Autores principales:	Sendra, Luis, Miguel, Antonio, Pérez-Enguix, Daniel, Herrero, María José, Montalvá, Eva, García-Gimeno, María Adelaida, Noguera, Inmaculada, Díaz, Ana, Pérez, Judith, Sanz, Pascual, López-Andújar, Rafael, Martí-Bonmatí, Luis, Aliño, Salvador F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047531/ https://www.ncbi.nlm.nih.gov/pubmed/27695064 http://dx.doi.org/10.1371/journal.pone.0163898

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