The Fatty Acid Synthase Inhibitor Platensimycin Improves Insulin Resistance without Inducing Liver Steatosis in Mice and Monkeys

OBJECTIVES: Platensimycin (PTM) is a natural antibiotic produced by Streptomyces platensis that selectively inhibits bacterial and mammalian fatty acid synthase (FAS) without affecting synthesis of other lipids. Recently, we reported that oral administration of PTM in mouse models (db/db and db/+) w...

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Detalles Bibliográficos
Autores principales: Singh, Sheo B., Kang, Ling, Nawrocki, Andrea R., Zhou, Dan, Wu, Margaret, Previs, Stephen, Miller, Corey, Liu, Haiying, Hines, Catherine D. G., Madeira, Maria, Cao, Jin, Herath, Kithsiri, Wang, Liangsu, Kelley, David E., Li, Cai, Guan, Hong-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047649/
https://www.ncbi.nlm.nih.gov/pubmed/27695056
http://dx.doi.org/10.1371/journal.pone.0164133

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