A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses

Although β-blockers can be used to eliminate stress-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), this treatment is unsuccessful in ∼25% of cases. Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) generated from these pat...

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Detalles Bibliográficos
Autores principales: Preininger, Marcela K., Jha, Rajneesh, Maxwell, Joshua T., Wu, Qingling, Singh, Monalisa, Wang, Bo, Dalal, Aarti, Mceachin, Zachary T., Rossoll, Wilfried, Hales, Chadwick M., Fischbach, Peter S., Wagner, Mary B., Xu, Chunhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047684/
https://www.ncbi.nlm.nih.gov/pubmed/27491078
http://dx.doi.org/10.1242/dmm.026823

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