A knockin mouse model for human ATP4a(R703C) mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies

By whole exome sequencing, we recently identified a missense mutation (p.R703C) in the human ATP4a gene, which encodes the proton pump responsible for gastric acidification. This mutation causes an aggressive familial type I gastric neuroendocrine tumor in homozygous individuals. Affected individual...

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Detalles Bibliográficos
Autores principales: Calvete, Oriol, Varro, Andrea, Pritchard, D. Mark, Barroso, Alicia, Oteo, Marta, Morcillo, Miguel Ángel, Vargiu, Pierfrancesco, Dodd, Steven, Garcia, Miriam, Reyes, José, Ortega, Sagrario, Benitez, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047686/
https://www.ncbi.nlm.nih.gov/pubmed/27491072
http://dx.doi.org/10.1242/dmm.025890

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