Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease

Polycystic kidney disease (PKD) is characterized by slow expansion of fluid-filled cysts derived from tubules within the kidney. Cystic expansion results in injury to surrounding parenchyma and leads to inflammation, scarring and ultimately loss of renal function. Macrophages are a key element in th...

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Detalles Bibliográficos
Autores principales: Peda, Jacqueline D., Salah, Sally M., Wallace, Darren P., Fields, Patrick E., Grantham, Connor J., Fields, Timothy A., Swenson-Fields, Katherine I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047688/
https://www.ncbi.nlm.nih.gov/pubmed/27491076
http://dx.doi.org/10.1242/dmm.024745

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047688/
https://www.ncbi.nlm.nih.gov/pubmed/27491076
http://dx.doi.org/10.1242/dmm.024745

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