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Rasagiline for sleep disorders in patients with Parkinson’s disease: a prospective observational study

INTRODUCTION: Rasagiline is a selective, irreversible monoamine oxidase B inhibitor that ameliorates the symptoms of Parkinson’s disease (PD) by inhibiting striatal dopamine metabolism. There is also evidence that monoamine oxidase B inhibitors increase melatonin levels in the pineal gland and may h...

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Autores principales: Schettino, Carla, Dato, Clemente, Capaldo, Guglielmo, Sampaolo, Simone, Di Iorio, Giuseppe, Melone, Mariarosa AB
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047735/
https://www.ncbi.nlm.nih.gov/pubmed/27729794
http://dx.doi.org/10.2147/NDT.S116476
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author Schettino, Carla
Dato, Clemente
Capaldo, Guglielmo
Sampaolo, Simone
Di Iorio, Giuseppe
Melone, Mariarosa AB
author_facet Schettino, Carla
Dato, Clemente
Capaldo, Guglielmo
Sampaolo, Simone
Di Iorio, Giuseppe
Melone, Mariarosa AB
author_sort Schettino, Carla
collection PubMed
description INTRODUCTION: Rasagiline is a selective, irreversible monoamine oxidase B inhibitor that ameliorates the symptoms of Parkinson’s disease (PD) by inhibiting striatal dopamine metabolism. There is also evidence that monoamine oxidase B inhibitors increase melatonin levels in the pineal gland and may have a beneficial effect on sleep disorders, which are a common feature in patients with PD. METHODS: This single-center, prospective, observational, 12-week study compared the effect of combination therapy with levodopa 200–300 mg/d + rasagiline 1 mg/d (n=19) with levodopa 200–300 mg/d alone (n=19) in the treatment of sleep disorders in patients with idiopathic PD. RESULTS: After 12 weeks’ treatment, mean sleep latency was significantly (P<0.001) lower and the improvement in sleep latency from baseline was significantly (P=0.001) greater in patients receiving levodopa + rasagiline than in patients receiving levodopa alone. Similarly, at the end of the study, the mean total sleep time was significantly (P=0.002) longer and the improvement from baseline in mean total sleep time was significantly (P=0.026) greater in patients receiving levodopa + rasagiline than levodopa alone. There were no significant differences between treatment groups for the mean number of awakenings reported at week 12 nor the change from baseline to week 12 in mean number of awakenings. CONCLUSION: Adding rasagiline to levodopa improved sleep outcomes and may be an appropriate option for patients with PD experiencing sleep disorders.
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spelling pubmed-50477352016-10-11 Rasagiline for sleep disorders in patients with Parkinson’s disease: a prospective observational study Schettino, Carla Dato, Clemente Capaldo, Guglielmo Sampaolo, Simone Di Iorio, Giuseppe Melone, Mariarosa AB Neuropsychiatr Dis Treat Original Research INTRODUCTION: Rasagiline is a selective, irreversible monoamine oxidase B inhibitor that ameliorates the symptoms of Parkinson’s disease (PD) by inhibiting striatal dopamine metabolism. There is also evidence that monoamine oxidase B inhibitors increase melatonin levels in the pineal gland and may have a beneficial effect on sleep disorders, which are a common feature in patients with PD. METHODS: This single-center, prospective, observational, 12-week study compared the effect of combination therapy with levodopa 200–300 mg/d + rasagiline 1 mg/d (n=19) with levodopa 200–300 mg/d alone (n=19) in the treatment of sleep disorders in patients with idiopathic PD. RESULTS: After 12 weeks’ treatment, mean sleep latency was significantly (P<0.001) lower and the improvement in sleep latency from baseline was significantly (P=0.001) greater in patients receiving levodopa + rasagiline than in patients receiving levodopa alone. Similarly, at the end of the study, the mean total sleep time was significantly (P=0.002) longer and the improvement from baseline in mean total sleep time was significantly (P=0.026) greater in patients receiving levodopa + rasagiline than levodopa alone. There were no significant differences between treatment groups for the mean number of awakenings reported at week 12 nor the change from baseline to week 12 in mean number of awakenings. CONCLUSION: Adding rasagiline to levodopa improved sleep outcomes and may be an appropriate option for patients with PD experiencing sleep disorders. Dove Medical Press 2016-09-29 /pmc/articles/PMC5047735/ /pubmed/27729794 http://dx.doi.org/10.2147/NDT.S116476 Text en © 2016 Schettino et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Schettino, Carla
Dato, Clemente
Capaldo, Guglielmo
Sampaolo, Simone
Di Iorio, Giuseppe
Melone, Mariarosa AB
Rasagiline for sleep disorders in patients with Parkinson’s disease: a prospective observational study
title Rasagiline for sleep disorders in patients with Parkinson’s disease: a prospective observational study
title_full Rasagiline for sleep disorders in patients with Parkinson’s disease: a prospective observational study
title_fullStr Rasagiline for sleep disorders in patients with Parkinson’s disease: a prospective observational study
title_full_unstemmed Rasagiline for sleep disorders in patients with Parkinson’s disease: a prospective observational study
title_short Rasagiline for sleep disorders in patients with Parkinson’s disease: a prospective observational study
title_sort rasagiline for sleep disorders in patients with parkinson’s disease: a prospective observational study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047735/
https://www.ncbi.nlm.nih.gov/pubmed/27729794
http://dx.doi.org/10.2147/NDT.S116476
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