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Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model
OBJECTIVE: To study the effect of Yisui Tongjing (YSTJ) prescription on motor nerve conduction velocity (MNCV) and microstructure of the sciatic nerve in experimental autoimmune neuritis (EAN) rats, the Guillain–Barré syndrome classic animal models. MATERIALS AND METHODS: In this study, we establish...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047740/ https://www.ncbi.nlm.nih.gov/pubmed/27729792 http://dx.doi.org/10.2147/NDT.S110813 |
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author | Zhang, Erli Li, Mingquan Zhao, Jianjun Dong, Yuxiang Yang, Xueqin Huang, Jingbo |
author_facet | Zhang, Erli Li, Mingquan Zhao, Jianjun Dong, Yuxiang Yang, Xueqin Huang, Jingbo |
author_sort | Zhang, Erli |
collection | PubMed |
description | OBJECTIVE: To study the effect of Yisui Tongjing (YSTJ) prescription on motor nerve conduction velocity (MNCV) and microstructure of the sciatic nerve in experimental autoimmune neuritis (EAN) rats, the Guillain–Barré syndrome classic animal models. MATERIALS AND METHODS: In this study, we established an EAN model in Lewis rats by immunization. We evaluated the potential clinical application of a traditional Chinese medicine YSTJ by intragastric administration and compared its effect with immunoglobulin. The sciatic MNCV was measured by electrophysiology experiment. Hematoxylin–eosin staining and transmission electron microscope analysis were used to determine the pathologically morphological changes before and after YSTJ application. RESULTS: We found that application of YSTJ could significantly alleviate the clinical signs in EAN rats. The treatment also increased MNCV in the sciatic nerve compared to that in the untreated nerve. Demyelination in the sciatic nerve in EAN rats was significantly ameliorated, and newly generated myelinated nerve fibers were observed with treatment of high dose of YSTJ. CONCLUSION: This study showed that the traditional Chinese medicine YSTJ was likely to serve as a therapeutic medicine in autoimmune neuropathies, providing an effective and economic means to the treatment of Guillain–Barré syndrome. |
format | Online Article Text |
id | pubmed-5047740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-50477402016-10-11 Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model Zhang, Erli Li, Mingquan Zhao, Jianjun Dong, Yuxiang Yang, Xueqin Huang, Jingbo Neuropsychiatr Dis Treat Original Research OBJECTIVE: To study the effect of Yisui Tongjing (YSTJ) prescription on motor nerve conduction velocity (MNCV) and microstructure of the sciatic nerve in experimental autoimmune neuritis (EAN) rats, the Guillain–Barré syndrome classic animal models. MATERIALS AND METHODS: In this study, we established an EAN model in Lewis rats by immunization. We evaluated the potential clinical application of a traditional Chinese medicine YSTJ by intragastric administration and compared its effect with immunoglobulin. The sciatic MNCV was measured by electrophysiology experiment. Hematoxylin–eosin staining and transmission electron microscope analysis were used to determine the pathologically morphological changes before and after YSTJ application. RESULTS: We found that application of YSTJ could significantly alleviate the clinical signs in EAN rats. The treatment also increased MNCV in the sciatic nerve compared to that in the untreated nerve. Demyelination in the sciatic nerve in EAN rats was significantly ameliorated, and newly generated myelinated nerve fibers were observed with treatment of high dose of YSTJ. CONCLUSION: This study showed that the traditional Chinese medicine YSTJ was likely to serve as a therapeutic medicine in autoimmune neuropathies, providing an effective and economic means to the treatment of Guillain–Barré syndrome. Dove Medical Press 2016-09-29 /pmc/articles/PMC5047740/ /pubmed/27729792 http://dx.doi.org/10.2147/NDT.S110813 Text en © 2016 This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Zhang, Erli Li, Mingquan Zhao, Jianjun Dong, Yuxiang Yang, Xueqin Huang, Jingbo Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model |
title | Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model |
title_full | Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model |
title_fullStr | Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model |
title_full_unstemmed | Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model |
title_short | Traditional Chinese medicine Yisui Tongjing relieved neural severity in experimental autoimmune neuritis rat model |
title_sort | traditional chinese medicine yisui tongjing relieved neural severity in experimental autoimmune neuritis rat model |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047740/ https://www.ncbi.nlm.nih.gov/pubmed/27729792 http://dx.doi.org/10.2147/NDT.S110813 |
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