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Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma

BACKGROUND: Epidemiological studies have provided strong evidence that fine particulate matter (PM2.5; aerodynamic diameter ≤ 2.5 μm) can exacerbate asthmatic symptoms in children. Pro-oxidant components of PM2.5 are capable of directly generating reactive oxygen species. Oxidative burden is used to...

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Autores principales: Maikawa, Caitlin L., Weichenthal, Scott, Wheeler, Amanda J., Dobbin, Nina A., Smargiassi, Audrey, Evans, Greg, Liu, Ling, Goldberg, Mark S., Pollitt, Krystal J. Godri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047770/
https://www.ncbi.nlm.nih.gov/pubmed/27152705
http://dx.doi.org/10.1289/EHP175
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author Maikawa, Caitlin L.
Weichenthal, Scott
Wheeler, Amanda J.
Dobbin, Nina A.
Smargiassi, Audrey
Evans, Greg
Liu, Ling
Goldberg, Mark S.
Pollitt, Krystal J. Godri
author_facet Maikawa, Caitlin L.
Weichenthal, Scott
Wheeler, Amanda J.
Dobbin, Nina A.
Smargiassi, Audrey
Evans, Greg
Liu, Ling
Goldberg, Mark S.
Pollitt, Krystal J. Godri
author_sort Maikawa, Caitlin L.
collection PubMed
description BACKGROUND: Epidemiological studies have provided strong evidence that fine particulate matter (PM2.5; aerodynamic diameter ≤ 2.5 μm) can exacerbate asthmatic symptoms in children. Pro-oxidant components of PM2.5 are capable of directly generating reactive oxygen species. Oxidative burden is used to describe the capacity of PM2.5 to generate reactive oxygen species in the lung. OBJECTIVE: In this study we investigated the association between airway inflammation in asthmatic children and oxidative burden of PM2.5 personal exposure. METHODS: Daily PM2.5 personal exposure samples (n = 249) of 62 asthmatic school-aged children in Montreal were collected over 10 consecutive days. The oxidative burden of PM2.5 samples was determined in vitro as the depletion of low-molecular-weight antioxidants (ascorbate and glutathione) from a synthetic model of the fluid lining the respiratory tract. Airway inflammation was measured daily as fractional exhaled nitric oxide (FeNO). RESULTS: A positive association was identified between FeNO and glutathione-related oxidative burden exposure in the previous 24 hr (6.0% increase per interquartile range change in glutathione). Glutathione-related oxidative burden was further found to be positively associated with FeNO over 1-day lag and 2-day lag periods. Results further demonstrate that corticosteroid use may reduce the FeNO response to elevated glutathione-related oxidative burden exposure (no use, 15.8%; irregular use, 3.8%), whereas mold (22.1%), dust (10.6%), or fur (13.1%) allergies may increase FeNO in children with versus children without these allergies (11.5%). No association was found between PM2.5 mass or ascorbate-related oxidative burden and FeNO levels. CONCLUSIONS: Exposure to PM2.5 with elevated glutathione-related oxidative burden was associated with increased FeNO. CITATION: Maikawa CL, Weichenthal S, Wheeler AJ, Dobbin NA, Smargiassi A, Evans G, Liu L, Goldberg MS, Godri Pollitt KJ. 2016. Particulate oxidative burden as a predictor of exhaled nitric oxide in children with asthma. Environ Health Perspect 124:1616–1622; http://dx.doi.org/10.1289/EHP175
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spelling pubmed-50477702016-10-10 Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma Maikawa, Caitlin L. Weichenthal, Scott Wheeler, Amanda J. Dobbin, Nina A. Smargiassi, Audrey Evans, Greg Liu, Ling Goldberg, Mark S. Pollitt, Krystal J. Godri Environ Health Perspect Children's Health BACKGROUND: Epidemiological studies have provided strong evidence that fine particulate matter (PM2.5; aerodynamic diameter ≤ 2.5 μm) can exacerbate asthmatic symptoms in children. Pro-oxidant components of PM2.5 are capable of directly generating reactive oxygen species. Oxidative burden is used to describe the capacity of PM2.5 to generate reactive oxygen species in the lung. OBJECTIVE: In this study we investigated the association between airway inflammation in asthmatic children and oxidative burden of PM2.5 personal exposure. METHODS: Daily PM2.5 personal exposure samples (n = 249) of 62 asthmatic school-aged children in Montreal were collected over 10 consecutive days. The oxidative burden of PM2.5 samples was determined in vitro as the depletion of low-molecular-weight antioxidants (ascorbate and glutathione) from a synthetic model of the fluid lining the respiratory tract. Airway inflammation was measured daily as fractional exhaled nitric oxide (FeNO). RESULTS: A positive association was identified between FeNO and glutathione-related oxidative burden exposure in the previous 24 hr (6.0% increase per interquartile range change in glutathione). Glutathione-related oxidative burden was further found to be positively associated with FeNO over 1-day lag and 2-day lag periods. Results further demonstrate that corticosteroid use may reduce the FeNO response to elevated glutathione-related oxidative burden exposure (no use, 15.8%; irregular use, 3.8%), whereas mold (22.1%), dust (10.6%), or fur (13.1%) allergies may increase FeNO in children with versus children without these allergies (11.5%). No association was found between PM2.5 mass or ascorbate-related oxidative burden and FeNO levels. CONCLUSIONS: Exposure to PM2.5 with elevated glutathione-related oxidative burden was associated with increased FeNO. CITATION: Maikawa CL, Weichenthal S, Wheeler AJ, Dobbin NA, Smargiassi A, Evans G, Liu L, Goldberg MS, Godri Pollitt KJ. 2016. Particulate oxidative burden as a predictor of exhaled nitric oxide in children with asthma. Environ Health Perspect 124:1616–1622; http://dx.doi.org/10.1289/EHP175 National Institute of Environmental Health Sciences 2016-05-06 2016-10 /pmc/articles/PMC5047770/ /pubmed/27152705 http://dx.doi.org/10.1289/EHP175 Text en http://creativecommons.org/publicdomain/mark/1.0/ Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, “Reproduced with permission from Environmental Health Perspectives”); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright.
spellingShingle Children's Health
Maikawa, Caitlin L.
Weichenthal, Scott
Wheeler, Amanda J.
Dobbin, Nina A.
Smargiassi, Audrey
Evans, Greg
Liu, Ling
Goldberg, Mark S.
Pollitt, Krystal J. Godri
Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma
title Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma
title_full Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma
title_fullStr Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma
title_full_unstemmed Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma
title_short Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma
title_sort particulate oxidative burden as a predictor of exhaled nitric oxide in children with asthma
topic Children's Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047770/
https://www.ncbi.nlm.nih.gov/pubmed/27152705
http://dx.doi.org/10.1289/EHP175
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