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Measuring indirect effects of rotavirus vaccine in low income countries
Widespread introduction of rotavirus vaccines has led to major reductions in the burden of rotavirus gastroenteritis worldwide. Vaccine effectiveness is diminished, however, in low income countries, that harbour the greatest burden of rotavirus attributed morbidity and mortality. Indirect effects of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047945/ https://www.ncbi.nlm.nih.gov/pubmed/27443593 http://dx.doi.org/10.1016/j.vaccine.2016.07.001 |
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author | Bennett, Aisleen Bar-Zeev, Naor Cunliffe, Nigel A. |
author_facet | Bennett, Aisleen Bar-Zeev, Naor Cunliffe, Nigel A. |
author_sort | Bennett, Aisleen |
collection | PubMed |
description | Widespread introduction of rotavirus vaccines has led to major reductions in the burden of rotavirus gastroenteritis worldwide. Vaccine effectiveness is diminished, however, in low income countries, that harbour the greatest burden of rotavirus attributed morbidity and mortality. Indirect effects of rotavirus vaccine (herd immunity and herd protection) could increase population level impact and improve vaccine cost effectiveness in such settings. While rotavirus vaccine indirect effects have been demonstrated in high and middle income countries, there are very little data from low income countries where force of infection, population structures and vaccine schedules differ. Targeted efforts to evaluate indirect effects of rotavirus vaccine in low income countries are required to understand the total impact of rotavirus vaccine on the global burden of rotavirus disease. |
format | Online Article Text |
id | pubmed-5047945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-50479452016-10-07 Measuring indirect effects of rotavirus vaccine in low income countries Bennett, Aisleen Bar-Zeev, Naor Cunliffe, Nigel A. Vaccine Commentary Widespread introduction of rotavirus vaccines has led to major reductions in the burden of rotavirus gastroenteritis worldwide. Vaccine effectiveness is diminished, however, in low income countries, that harbour the greatest burden of rotavirus attributed morbidity and mortality. Indirect effects of rotavirus vaccine (herd immunity and herd protection) could increase population level impact and improve vaccine cost effectiveness in such settings. While rotavirus vaccine indirect effects have been demonstrated in high and middle income countries, there are very little data from low income countries where force of infection, population structures and vaccine schedules differ. Targeted efforts to evaluate indirect effects of rotavirus vaccine in low income countries are required to understand the total impact of rotavirus vaccine on the global burden of rotavirus disease. Elsevier Science 2016-08-17 /pmc/articles/PMC5047945/ /pubmed/27443593 http://dx.doi.org/10.1016/j.vaccine.2016.07.001 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Commentary Bennett, Aisleen Bar-Zeev, Naor Cunliffe, Nigel A. Measuring indirect effects of rotavirus vaccine in low income countries |
title | Measuring indirect effects of rotavirus vaccine in low income countries |
title_full | Measuring indirect effects of rotavirus vaccine in low income countries |
title_fullStr | Measuring indirect effects of rotavirus vaccine in low income countries |
title_full_unstemmed | Measuring indirect effects of rotavirus vaccine in low income countries |
title_short | Measuring indirect effects of rotavirus vaccine in low income countries |
title_sort | measuring indirect effects of rotavirus vaccine in low income countries |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047945/ https://www.ncbi.nlm.nih.gov/pubmed/27443593 http://dx.doi.org/10.1016/j.vaccine.2016.07.001 |
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