Cargando…

Measuring indirect effects of rotavirus vaccine in low income countries

Widespread introduction of rotavirus vaccines has led to major reductions in the burden of rotavirus gastroenteritis worldwide. Vaccine effectiveness is diminished, however, in low income countries, that harbour the greatest burden of rotavirus attributed morbidity and mortality. Indirect effects of...

Descripción completa

Detalles Bibliográficos
Autores principales: Bennett, Aisleen, Bar-Zeev, Naor, Cunliffe, Nigel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047945/
https://www.ncbi.nlm.nih.gov/pubmed/27443593
http://dx.doi.org/10.1016/j.vaccine.2016.07.001
_version_ 1782457503262441472
author Bennett, Aisleen
Bar-Zeev, Naor
Cunliffe, Nigel A.
author_facet Bennett, Aisleen
Bar-Zeev, Naor
Cunliffe, Nigel A.
author_sort Bennett, Aisleen
collection PubMed
description Widespread introduction of rotavirus vaccines has led to major reductions in the burden of rotavirus gastroenteritis worldwide. Vaccine effectiveness is diminished, however, in low income countries, that harbour the greatest burden of rotavirus attributed morbidity and mortality. Indirect effects of rotavirus vaccine (herd immunity and herd protection) could increase population level impact and improve vaccine cost effectiveness in such settings. While rotavirus vaccine indirect effects have been demonstrated in high and middle income countries, there are very little data from low income countries where force of infection, population structures and vaccine schedules differ. Targeted efforts to evaluate indirect effects of rotavirus vaccine in low income countries are required to understand the total impact of rotavirus vaccine on the global burden of rotavirus disease.
format Online
Article
Text
id pubmed-5047945
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Elsevier Science
record_format MEDLINE/PubMed
spelling pubmed-50479452016-10-07 Measuring indirect effects of rotavirus vaccine in low income countries Bennett, Aisleen Bar-Zeev, Naor Cunliffe, Nigel A. Vaccine Commentary Widespread introduction of rotavirus vaccines has led to major reductions in the burden of rotavirus gastroenteritis worldwide. Vaccine effectiveness is diminished, however, in low income countries, that harbour the greatest burden of rotavirus attributed morbidity and mortality. Indirect effects of rotavirus vaccine (herd immunity and herd protection) could increase population level impact and improve vaccine cost effectiveness in such settings. While rotavirus vaccine indirect effects have been demonstrated in high and middle income countries, there are very little data from low income countries where force of infection, population structures and vaccine schedules differ. Targeted efforts to evaluate indirect effects of rotavirus vaccine in low income countries are required to understand the total impact of rotavirus vaccine on the global burden of rotavirus disease. Elsevier Science 2016-08-17 /pmc/articles/PMC5047945/ /pubmed/27443593 http://dx.doi.org/10.1016/j.vaccine.2016.07.001 Text en © 2016 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Commentary
Bennett, Aisleen
Bar-Zeev, Naor
Cunliffe, Nigel A.
Measuring indirect effects of rotavirus vaccine in low income countries
title Measuring indirect effects of rotavirus vaccine in low income countries
title_full Measuring indirect effects of rotavirus vaccine in low income countries
title_fullStr Measuring indirect effects of rotavirus vaccine in low income countries
title_full_unstemmed Measuring indirect effects of rotavirus vaccine in low income countries
title_short Measuring indirect effects of rotavirus vaccine in low income countries
title_sort measuring indirect effects of rotavirus vaccine in low income countries
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047945/
https://www.ncbi.nlm.nih.gov/pubmed/27443593
http://dx.doi.org/10.1016/j.vaccine.2016.07.001
work_keys_str_mv AT bennettaisleen measuringindirecteffectsofrotavirusvaccineinlowincomecountries
AT barzeevnaor measuringindirecteffectsofrotavirusvaccineinlowincomecountries
AT cunliffenigela measuringindirecteffectsofrotavirusvaccineinlowincomecountries