The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial–mesenchymal transition

Epithelial tumor cells often acquire malignant properties, such as invasion/metastasis and uncontrolled cell growth, by undergoing epithelial–mesenchymal transition (EMT). However, the mechanisms by which EMT contributes to malignant progression remain elusive. Here we show that the Rho guanine nucl...

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Detalles Bibliográficos
Autores principales: Komiya, Y, Onodera, Y, Kuroiwa, M, Nomimura, S, Kubo, Y, Nam, J-M, Kajiwara, K, Nada, S, Oneyama, C, Sabe, H, Okada, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5047960/
https://www.ncbi.nlm.nih.gov/pubmed/27617642
http://dx.doi.org/10.1038/oncsis.2016.59

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