Cargando…
Population Pharmacokinetic Analysis of Piperacillin/Tazobactam in Korean Patients with Acute Infections
BACKGROUND: For more effective and safer usage of antibiotics, the dosing strategy should be individualized based on the patients’ characteristics, including race. The aim of this study was to investigate the population pharmacokinetic (PK) profiles of piperacillin and tazobactam in Korean patients...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Infectious Diseases and Korean Society for Chemotherapy
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048002/ https://www.ncbi.nlm.nih.gov/pubmed/27659435 http://dx.doi.org/10.3947/ic.2016.48.3.209 |
_version_ | 1782457516379078656 |
---|---|
author | Kim, Yong Kyun Jung, Jin Ah Choi, Hyang-Ki Bae, In-Gyu Choi, Won Suk Hur, Jian Jin, Sung Joon Kim, Shin-Woo Kwon, Ki Tae Lee, Sang-Rok Shin, Jae-Gook Kiem, Sungmin |
author_facet | Kim, Yong Kyun Jung, Jin Ah Choi, Hyang-Ki Bae, In-Gyu Choi, Won Suk Hur, Jian Jin, Sung Joon Kim, Shin-Woo Kwon, Ki Tae Lee, Sang-Rok Shin, Jae-Gook Kiem, Sungmin |
author_sort | Kim, Yong Kyun |
collection | PubMed |
description | BACKGROUND: For more effective and safer usage of antibiotics, the dosing strategy should be individualized based on the patients’ characteristics, including race. The aim of this study was to investigate the population pharmacokinetic (PK) profiles of piperacillin and tazobactam in Korean patients with acute infections. MATERIALS AND METHODS: At least four consecutive 2/0.25 g or 4/0.5 g doses of piperacillin/tazobactam (TZP) were intravenously infused over 1 h every 8 h for patients with creatinine clearance (CL(cr)) ≤50 ml/min or CL(cr) >50 mL/min, respectively. Blood samples from 33 patients at a steady-state were taken pre-dose and at 0 min, 30 min, and 4-6 h after the fourth infusion. The population PK analysis was conducted using a non-linear mixed-effects method. A likelihood ratio test was used to select significant covariates, with significance levels of P <0.05 for selection and P <0.01 for elimination. RESULTS: Both piperacillin PK and tazobactam PK were well described by a two-compartment model with first-order elimination. Creatinine clearance and body weight, as covariates on clearance (CL) and volume of central compartment (V1), were selected among the covariates possibly affecting PK parameters of both drugs. CL was defined as CL = 2.9 + 4.03 × CL(cr) /47 for piperacillin and CL = 1.76 + 4.81 × CL(cr) /47 for tazobactam. V1 was defined as V1 = 19.5 × weight/60 for piperacillin and V1 = 22.6 × weight/60 for tazobactam. CONCLUSION: The PK profiles of TZP at a steady-state in Korean patients with acute infections were well described by a two-compartment model with first-order elimination. Both piperacillin and tazobactam clearances were significantly influenced by creatinine clearance. |
format | Online Article Text |
id | pubmed-5048002 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Society of Infectious Diseases and Korean Society for Chemotherapy |
record_format | MEDLINE/PubMed |
spelling | pubmed-50480022016-10-04 Population Pharmacokinetic Analysis of Piperacillin/Tazobactam in Korean Patients with Acute Infections Kim, Yong Kyun Jung, Jin Ah Choi, Hyang-Ki Bae, In-Gyu Choi, Won Suk Hur, Jian Jin, Sung Joon Kim, Shin-Woo Kwon, Ki Tae Lee, Sang-Rok Shin, Jae-Gook Kiem, Sungmin Infect Chemother Original Article BACKGROUND: For more effective and safer usage of antibiotics, the dosing strategy should be individualized based on the patients’ characteristics, including race. The aim of this study was to investigate the population pharmacokinetic (PK) profiles of piperacillin and tazobactam in Korean patients with acute infections. MATERIALS AND METHODS: At least four consecutive 2/0.25 g or 4/0.5 g doses of piperacillin/tazobactam (TZP) were intravenously infused over 1 h every 8 h for patients with creatinine clearance (CL(cr)) ≤50 ml/min or CL(cr) >50 mL/min, respectively. Blood samples from 33 patients at a steady-state were taken pre-dose and at 0 min, 30 min, and 4-6 h after the fourth infusion. The population PK analysis was conducted using a non-linear mixed-effects method. A likelihood ratio test was used to select significant covariates, with significance levels of P <0.05 for selection and P <0.01 for elimination. RESULTS: Both piperacillin PK and tazobactam PK were well described by a two-compartment model with first-order elimination. Creatinine clearance and body weight, as covariates on clearance (CL) and volume of central compartment (V1), were selected among the covariates possibly affecting PK parameters of both drugs. CL was defined as CL = 2.9 + 4.03 × CL(cr) /47 for piperacillin and CL = 1.76 + 4.81 × CL(cr) /47 for tazobactam. V1 was defined as V1 = 19.5 × weight/60 for piperacillin and V1 = 22.6 × weight/60 for tazobactam. CONCLUSION: The PK profiles of TZP at a steady-state in Korean patients with acute infections were well described by a two-compartment model with first-order elimination. Both piperacillin and tazobactam clearances were significantly influenced by creatinine clearance. The Korean Society of Infectious Diseases and Korean Society for Chemotherapy 2016-09 2016-09-06 /pmc/articles/PMC5048002/ /pubmed/27659435 http://dx.doi.org/10.3947/ic.2016.48.3.209 Text en Copyright © 2016 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Yong Kyun Jung, Jin Ah Choi, Hyang-Ki Bae, In-Gyu Choi, Won Suk Hur, Jian Jin, Sung Joon Kim, Shin-Woo Kwon, Ki Tae Lee, Sang-Rok Shin, Jae-Gook Kiem, Sungmin Population Pharmacokinetic Analysis of Piperacillin/Tazobactam in Korean Patients with Acute Infections |
title | Population Pharmacokinetic Analysis of Piperacillin/Tazobactam in Korean Patients with Acute Infections |
title_full | Population Pharmacokinetic Analysis of Piperacillin/Tazobactam in Korean Patients with Acute Infections |
title_fullStr | Population Pharmacokinetic Analysis of Piperacillin/Tazobactam in Korean Patients with Acute Infections |
title_full_unstemmed | Population Pharmacokinetic Analysis of Piperacillin/Tazobactam in Korean Patients with Acute Infections |
title_short | Population Pharmacokinetic Analysis of Piperacillin/Tazobactam in Korean Patients with Acute Infections |
title_sort | population pharmacokinetic analysis of piperacillin/tazobactam in korean patients with acute infections |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048002/ https://www.ncbi.nlm.nih.gov/pubmed/27659435 http://dx.doi.org/10.3947/ic.2016.48.3.209 |
work_keys_str_mv | AT kimyongkyun populationpharmacokineticanalysisofpiperacillintazobactaminkoreanpatientswithacuteinfections AT jungjinah populationpharmacokineticanalysisofpiperacillintazobactaminkoreanpatientswithacuteinfections AT choihyangki populationpharmacokineticanalysisofpiperacillintazobactaminkoreanpatientswithacuteinfections AT baeingyu populationpharmacokineticanalysisofpiperacillintazobactaminkoreanpatientswithacuteinfections AT choiwonsuk populationpharmacokineticanalysisofpiperacillintazobactaminkoreanpatientswithacuteinfections AT hurjian populationpharmacokineticanalysisofpiperacillintazobactaminkoreanpatientswithacuteinfections AT jinsungjoon populationpharmacokineticanalysisofpiperacillintazobactaminkoreanpatientswithacuteinfections AT kimshinwoo populationpharmacokineticanalysisofpiperacillintazobactaminkoreanpatientswithacuteinfections AT kwonkitae populationpharmacokineticanalysisofpiperacillintazobactaminkoreanpatientswithacuteinfections AT leesangrok populationpharmacokineticanalysisofpiperacillintazobactaminkoreanpatientswithacuteinfections AT shinjaegook populationpharmacokineticanalysisofpiperacillintazobactaminkoreanpatientswithacuteinfections AT kiemsungmin populationpharmacokineticanalysisofpiperacillintazobactaminkoreanpatientswithacuteinfections AT populationpharmacokineticanalysisofpiperacillintazobactaminkoreanpatientswithacuteinfections |