Deciphering KRAS and NRAS mutated clone dynamics in MLL-AF4 paediatric leukaemia by ultra deep sequencing analysis

To induce and sustain the leukaemogenic process, MLL-AF4+ leukaemia seems to require very few genetic alterations in addition to the fusion gene itself. Studies of infant and paediatric patients with MLL-AF4+ B cell precursor acute lymphoblastic leukaemia (BCP-ALL) have reported mutations in KRAS an...

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Detalles Bibliográficos
Autores principales: Trentin, Luca, Bresolin, Silvia, Giarin, Emanuela, Bardini, Michela, Serafin, Valentina, Accordi, Benedetta, Fais, Franco, Tenca, Claudya, De Lorenzo, Paola, Valsecchi, Maria Grazia, Cazzaniga, Giovanni, Kronnie, Geertruy te, Basso, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048141/
https://www.ncbi.nlm.nih.gov/pubmed/27698462
http://dx.doi.org/10.1038/srep34449

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