Intravital imaging reveals improved Kupffer cell-mediated phagocytosis as a mode of action of glycoengineered anti-CD20 antibodies

Anti-CD20 monoclonal antibodies (mAbs) represent an effective treatment for a number of B cell malignancies and autoimmune disorders. Glycoengineering of anti-CD20mAb may contribute to increased anti-tumor efficacy through enhanced antibody-dependent cellular cytotoxicity (ADCC) and phagocytosis (AD...

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Detalles Bibliográficos
Autores principales: Grandjean, Capucine L., Montalvao, Fabricio, Celli, Susanna, Michonneau, David, Breart, Beatrice, Garcia, Zacarias, Perro, Mario, Freytag, Olivier, Gerdes, Christian A., Bousso, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048169/
https://www.ncbi.nlm.nih.gov/pubmed/27698437
http://dx.doi.org/10.1038/srep34382

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