Evidence that COMT genotype and proline interact on negative-symptom outcomes in schizophrenia and bipolar disorder

Elevated peripheral proline is associated with psychiatric disorders, and there is evidence that proline is a neuromodulator. The proline dehydrogenase (PRODH) gene, which encodes the enzyme that catalyzes proline catabolism, maps to human chromosome 22q11.2, a region conferring risk of schizophreni...

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Detalles Bibliográficos
Autores principales: Clelland, C L, Drouet, V, Rilett, K C, Smeed, J A, Nadrich, R H, Rajparia, A, Read, L L, Clelland, J D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048199/
https://www.ncbi.nlm.nih.gov/pubmed/27622935
http://dx.doi.org/10.1038/tp.2016.157

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