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Unstable carotid artery plaque: new insights and controversies in diagnostics and treatment

Cardiovascular disease is estimated to be the leading cause of death, globally causing 14 million deaths each year. Stroke remains a massive public health problem and there is an increasing need for better strategies for the prevention and treatment of this disease. At least 20% of ischemic strokes...

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Detalles Bibliográficos
Autores principales: Skagen, Karolina, Skjelland, Mona, Zamani, Mahtab, Russell, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Croatian Medical Schools 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048225/
https://www.ncbi.nlm.nih.gov/pubmed/27586546
http://dx.doi.org/10.3325/cmj.2016.57.311
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author Skagen, Karolina
Skjelland, Mona
Zamani, Mahtab
Russell, David
author_facet Skagen, Karolina
Skjelland, Mona
Zamani, Mahtab
Russell, David
author_sort Skagen, Karolina
collection PubMed
description Cardiovascular disease is estimated to be the leading cause of death, globally causing 14 million deaths each year. Stroke remains a massive public health problem and there is an increasing need for better strategies for the prevention and treatment of this disease. At least 20% of ischemic strokes are thromboembolic in nature, caused by a thromboembolism from an atherosclerotic plaque at the carotid bifurcation or the internal carotid artery. Current clinical guidelines for both primary and secondary prevention of stroke in patients with carotid stenosis caused by atherosclerotic plaques remain reliant on general patient characteristics (traditional risk factors for stroke) and static measures of the degree of artery stenosis. Patients with similar traditional risk factors, however, have been found to have different risk of stroke, and it has in recent years become increasingly clear that the degree of artery stenosis alone is not the best estimation of stroke risk. There is a need for new methods for the assessment of stroke risk to improve risk prediction for the individual patient. This review aims to give an overview of new methods available for the identification of carotid plaque instability and the assessment of stroke risk.
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spelling pubmed-50482252016-10-17 Unstable carotid artery plaque: new insights and controversies in diagnostics and treatment Skagen, Karolina Skjelland, Mona Zamani, Mahtab Russell, David Croat Med J Review Cardiovascular disease is estimated to be the leading cause of death, globally causing 14 million deaths each year. Stroke remains a massive public health problem and there is an increasing need for better strategies for the prevention and treatment of this disease. At least 20% of ischemic strokes are thromboembolic in nature, caused by a thromboembolism from an atherosclerotic plaque at the carotid bifurcation or the internal carotid artery. Current clinical guidelines for both primary and secondary prevention of stroke in patients with carotid stenosis caused by atherosclerotic plaques remain reliant on general patient characteristics (traditional risk factors for stroke) and static measures of the degree of artery stenosis. Patients with similar traditional risk factors, however, have been found to have different risk of stroke, and it has in recent years become increasingly clear that the degree of artery stenosis alone is not the best estimation of stroke risk. There is a need for new methods for the assessment of stroke risk to improve risk prediction for the individual patient. This review aims to give an overview of new methods available for the identification of carotid plaque instability and the assessment of stroke risk. Croatian Medical Schools 2016-08 /pmc/articles/PMC5048225/ /pubmed/27586546 http://dx.doi.org/10.3325/cmj.2016.57.311 Text en Copyright © 2016 by the Croatian Medical Journal. All rights reserved. http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Skagen, Karolina
Skjelland, Mona
Zamani, Mahtab
Russell, David
Unstable carotid artery plaque: new insights and controversies in diagnostics and treatment
title Unstable carotid artery plaque: new insights and controversies in diagnostics and treatment
title_full Unstable carotid artery plaque: new insights and controversies in diagnostics and treatment
title_fullStr Unstable carotid artery plaque: new insights and controversies in diagnostics and treatment
title_full_unstemmed Unstable carotid artery plaque: new insights and controversies in diagnostics and treatment
title_short Unstable carotid artery plaque: new insights and controversies in diagnostics and treatment
title_sort unstable carotid artery plaque: new insights and controversies in diagnostics and treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048225/
https://www.ncbi.nlm.nih.gov/pubmed/27586546
http://dx.doi.org/10.3325/cmj.2016.57.311
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