Apocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state

The reactive-oxygen-species-(ROS)-generating-enzyme Nox2 is essential for leukocyte anti-microbial activity. However its role in cellular redox homeostasis and, consequently, in modulating intracellular signaling pathways remains unclear. Herein, we show Nox2 activation favors thioredoxin-1 (TRX-1)/...

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Detalles Bibliográficos
Autores principales: Trevelin, Silvia Cellone, dos Santos, Célio Xavier, Ferreira, Raphael Gomes, de Sá Lima, Larissa, Silva, Rangel Leal, Scavone, Cristoforo, Curi, Rui, Alves-Filho, José Carlos, Cunha, Thiago Mattar, Roxo-Júnior, Pérsio, Cervi, Maria-Célia, Laurindo, Francisco Rafael Martins, Hothersall, John Stephen, Cobb, Andrew M., Zhang, Min, Ivetic, Aleksandar, Shah, Ajay M., Lopes, Lucia Rossetti, Cunha, Fernando Queiroz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048297/
https://www.ncbi.nlm.nih.gov/pubmed/27698473
http://dx.doi.org/10.1038/srep34581

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