Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9

Heat shock factor 1 (HSF1) is a transcription factor that plays key roles in cancer, including providing a mechanism for cell survival under proteotoxic stress. Therefore, inhibition of the HSF1-stress pathway represents an exciting new opportunity in cancer treatment. We employed an unbiased phenot...

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Detalles Bibliográficos
Autores principales: Rye, Carl S., Chessum, Nicola E. A., Lamont, Scott, Pike, Kurt G., Faulder, Paul, Demeritt, Julie, Kemmitt, Paul, Tucker, Julie, Zani, Lorenzo, Cheeseman, Matthew D., Isaac, Rosie, Goodwin, Louise, Boros, Joanna, Raynaud, Florence, Hayes, Angela, Henley, Alan T., de Billy, Emmanuel, Lynch, Christopher J., Sharp, Swee Y., te Poele, Robert, Fee, Lisa O’, Foote, Kevin M., Green, Stephen, Workman, Paul, Jones, Keith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048338/
https://www.ncbi.nlm.nih.gov/pubmed/27746890
http://dx.doi.org/10.1039/c6md00159a

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