Cargando…

A novel injectable BRET-based in vivo imaging probe for detecting the activity of hypoxia-inducible factor regulated by the ubiquitin-proteasome system

The ubiquitin-proteasome system (UPS) is a selective protein degradation system that plays a critical role in many essential biological processes by regulating the existence of various cellular proteins. The target proteins of UPS are recognized and tagged with polyubiquitin chains by E3 ubiquitin l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kuchimaru, Takahiro, Suka, Tomoya, Hirota, Keisuke, Kadonosono, Tetsuya, Kizaka-Kondoh, Shinae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048432/ https://www.ncbi.nlm.nih.gov/pubmed/27698477 http://dx.doi.org/10.1038/srep34311

Ejemplares similares

In Vivo Imaging of HIF-Active Tumors by an Oxygen-Dependent Degradation Protein Probe with an Interchangeable Labeling System
por: Kuchimaru, Takahiro, et al.
Publicado: (2010)

Hypoxia‐inducible factor‐targeting prodrug TOP3 combined with gemcitabine or TS‐1 improves pancreatic cancer survival in an orthotopic model
por: Hoang, Ngoc Thi Hong, et al.
Publicado: (2016)

Bone resorption facilitates osteoblastic bone metastatic colonization by cooperation of insulin-like growth factor and hypoxia
por: Kuchimaru, Takahiro, et al.
Publicado: (2014)

In Vivo Imaging of Brain Ischemia Using an Oxygen-Dependent Degradative Fusion Protein Probe
por: Fujita, Youshi, et al.
Publicado: (2012)

In vivo optical imaging of tumor stromal cells with hypoxia‐inducible factor activity
por: Miyabara, Hitomi, et al.
Publicado: (2023)

A reliable murine model of bone metastasis by injecting cancer cells through caudal arteries
por: Kuchimaru, Takahiro, et al.
Publicado: (2018)

A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging
por: Kuchimaru, Takahiro, et al.
Publicado: (2016)

Detection of the Onset of Ischemia and Carcinogenesis by Hypoxia-Inducible Transcription Factor-Based In Vivo Bioluminescence Imaging
por: Kadonosono, Tetsuya, et al.
Publicado: (2011)

The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe
por: Takata, Shinsuke, et al.
Publicado: (2015)

A Fluorescent Protein Scaffold for Presenting Structurally Constrained Peptides Provides an Effective Screening System to Identify High Affinity Target-Binding Peptides
por: Kadonosono, Tetsuya, et al.
Publicado: (2014)

AGE/RAGE axis regulates reversible transition to quiescent states of ALK-rearranged NSCLC and pancreatic cancer cells in monolayer cultures
por: Kadonosono, Tetsuya, et al.
Publicado: (2022)

Novel adherent CD11b(+) Gr-1(+) tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment
por: Tsubaki, Takuya, et al.
Publicado: (2018)

Novel lymphoid enhancer‐binding factor 1‐cytoglobin axis promotes extravasation of osteosarcoma cells into the lungs
por: Pongsuchart, Mongkol, et al.
Publicado: (2018)

Slicing Spheroids in Microfluidic Devices for Morphological and Immunohistochemical Analysis
por: Kuriu, Satoru, et al.
Publicado: (2020)

Design Strategy to Create Antibody Mimetics Harbouring Immobilised Complementarity Determining Region Peptides for Practical Use
por: Kadonosono, Tetsuya, et al.
Publicado: (2020)

Strategic design to create HER2-targeting proteins with target-binding peptides immobilized on a fibronectin type III domain scaffold
por: Yimchuen, Wanaporn, et al.
Publicado: (2020)

Microfluidic Device for Screening for Target Cell-Specific Binding Molecules by Using Adherent Cells
por: Kaminaga, Maho, et al.
Publicado: (2019)

Antibody-guided design and identification of CD25-binding small antibody mimetics using mammalian cell surface display
por: See, Kyra, et al.
Publicado: (2021)

Microfluidic High-Migratory Cell Collector Suppressing Artifacts Caused by Microstructures
por: Ishida, Tadashi, et al.
Publicado: (2019)

Imaging and Targeting of the Hypoxia-inducible Factor 1-active Microenvironment
por: Kizaka-Kondoh, Shinae, et al.
Publicado: (2009)

Tissue-resident macrophages are major tumor-associated macrophage resources, contributing to early TNBC development, recurrence, and metastases
por: Hirano, Ryuichiro, et al.
Publicado: (2023)

VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells
por: Yoshida, Ayumi, et al.
Publicado: (2015)

Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells
por: Iizuka-Ohashi, Mahiro, et al.
Publicado: (2018)

In Vivo Visualization of Heterogeneous Intratumoral Distribution of Hypoxia-Inducible Factor-1α Activity by the Fusion of High-Resolution SPECT and Morphological Imaging Tests
por: Fujii, Hirofumi, et al.
Publicado: (2012)

High resolution imaging of intracellular oxygen concentration by phosphorescence lifetime
por: Kurokawa, Hiromi, et al.
Publicado: (2015)

Investigation of the Influence of Glucose Concentration on Cancer Cells by Using a Microfluidic Gradient Generator without the Induction of Large Shear Stress
por: Ishida, Tadashi, et al.
Publicado: (2016)

Experimental determination of the bioluminescence resonance energy transfer (BRET) Förster distances of NanoBRET and red-shifted BRET pairs
por: Weihs, Felix, et al.
Publicado: (2020)

In vivo imaging of long-term accumulation of cancer-derived exosomes using a BRET-based reporter
por: Hikita, Tomoya, et al.
Publicado: (2020)

The Medical Wisdom of Bret Harte
por: Bragman, Louis J.
Publicado: (1934)

Visualizing Ligand Binding to a GPCR In Vivo Using NanoBRET
por: Alcobia, Diana C., et al.
Publicado: (2018)

Hypoxia-induced alterations in the lung ubiquitin proteasome system during pulmonary hypertension pathogenesis
por: Wade, Brandy E., et al.
Publicado: (2018)

Evolution of BRET Biosensors from Live Cell to Tissue-Scale In vivo Imaging
por: De, Abhijit, et al.
Publicado: (2013)

In Vivo Label-Free Observation of Tumor-Related Blood Vessels in Small Animals Using a Newly Designed Photoacoustic 3D Imaging System
por: Asao, Yasufumi, et al.
Publicado: (2022)

Unraveling Receptor Stoichiometry Using Bret
por: Felce, James H., et al.
Publicado: (2012)

Developments in FRET- and BRET-Based Biosensors
por: Wu, Yuexin, et al.
Publicado: (2022)

The ubiquitin-proteasome pathway in cancer.
por: Spataro, V., et al.
Publicado: (1998)

The ubiquitin proteasome system in neuropathology
por: Lehman, Norman L.
Publicado: (2009)

The recognition of ubiquitinated proteins by the proteasome
por: Grice, Guinevere L., et al.
Publicado: (2016)

Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells
por: Yang, Xuan, et al.
Publicado: (2023)

Development of Cell Permeable NanoBRET Probes for the Measurement of PLK1 Target Engagement in Live Cells
por: Yang, Xuan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_9v8likccasp9bvahdrarj2e7m0