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Shock wave-induced ATP release from osteosarcoma U2OS cells promotes cellular uptake and cytotoxicity of methotrexate

BACKGROUND: Osteosarcoma is the most prevalent primary malignant bone tumor, but treatment is difficult and prognosis remains poor. Recently, large-dose chemotherapy has been shown to improve outcome but this approach can cause many side effects. Minimizing the dose of chemotherapeutic drugs and opt...

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Detalles Bibliográficos
Autores principales:	Qi, Baochang, Yu, Tiecheng, Wang, Chengxue, Wang, Tiejun, Yao, Jihang, Zhang, Xiaomeng, Deng, Pengfei, Xia, Yongning, Junger, Wolfgang G., Sun, Dahui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048460/ https://www.ncbi.nlm.nih.gov/pubmed/27716441 http://dx.doi.org/10.1186/s13046-016-0437-5

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