Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury

Isolated generalized dystonia is a central motor network disorder characterized by twisted movements or postures. The most frequent genetic cause is a GAG deletion in the Tor1a (DYT1) gene encoding torsinA with a reduced penetrance of 30-40 % suggesting additional genetic or environmental modifiers....

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Detalles Bibliográficos
Autores principales: Ip, Chi Wang, Isaias, Ioannis U., Kusche-Tekin, Burak B., Klein, Dennis, Groh, Janos, O’Leary, Aet, Knorr, Susanne, Higuchi, Takahiro, Koprich, James B., Brotchie, Jonathan M., Toyka, Klaus V., Reif, Andreas, Volkmann, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048687/
https://www.ncbi.nlm.nih.gov/pubmed/27716431
http://dx.doi.org/10.1186/s40478-016-0375-7

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