Intratumoral expression levels of PD-L1, GZMA, and HLA-A along with oligoclonal T cell expansion associate with response to nivolumab in metastatic melanoma

Immune checkpoint inhibitors blocking the interaction between programmed death-1 (PD-1) and PD-1 ligand-1 (PD-L1) are revolutionizing the cancer immunotherapies with durable clinical responses. Although high expression of PD-L1 in tumor tissues has been implicated to correlate with the better respon...

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Detalles Bibliográficos
Autores principales: Inoue, Hiroyuki, Park, Jae-Hyun, Kiyotani, Kazuma, Zewde, Makda, Miyashita, Azusa, Jinnin, Masatoshi, Kiniwa, Yukiko, Okuyama, Ryuhei, Tanaka, Ryota, Fujisawa, Yasuhiro, Kato, Hiroshi, Morita, Akimichi, Asai, Jun, Katoh, Norito, Yokota, Kenji, Akiyama, Masashi, Ihn, Hironobu, Fukushima, Satoshi, Nakamura, Yusuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5048759/
https://www.ncbi.nlm.nih.gov/pubmed/27757299
http://dx.doi.org/10.1080/2162402X.2016.1204507

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