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Irritable bowel syndrome might be associated with dry eye disease
BACKGROUND: A possible association between dry eye disease (DED) and irritable bowel syndrome (IBS) has been hypothesized based on the fact that they both share an inflammatory pathogenesis. METHODS: Ninety-five patients with IBS and 276 healthy controls were enrolled in the study. All patients answ...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hellenic Society of Gastroenterology
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049556/ https://www.ncbi.nlm.nih.gov/pubmed/27708515 http://dx.doi.org/10.20524/aog.2016.0064 |
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author | Asproudis, Ioannis Tsoumani, Anthoula T. Katsanos, Konstantinos H. Katsanos, Aristeidis H. Theopistos, Vasileios Paschidis, Konstantinos A. Tsianos, Epameinondas V. Christodoulou, Dimitrios |
author_facet | Asproudis, Ioannis Tsoumani, Anthoula T. Katsanos, Konstantinos H. Katsanos, Aristeidis H. Theopistos, Vasileios Paschidis, Konstantinos A. Tsianos, Epameinondas V. Christodoulou, Dimitrios |
author_sort | Asproudis, Ioannis |
collection | PubMed |
description | BACKGROUND: A possible association between dry eye disease (DED) and irritable bowel syndrome (IBS) has been hypothesized based on the fact that they both share an inflammatory pathogenesis. METHODS: Ninety-five patients with IBS and 276 healthy controls were enrolled in the study. All patients answered a questionnaire regarding DED symptoms and had a complete ophthalmic examination. DED signs were evaluated using Schirmer’s 1 and tear break-up time (tBUT) tests in both groups. RESULTS: Female IBS participants presented significantly lower Schirmer’s test and tBUT (P=0.002 and P<0.001 respectively) than controls. Both diagnostic tests in male IBS patients were also significantly lower than in controls (P<0.001). 72% of IBS patients gave at least 3 positive answers to the questionnaire compared with 42% of the control group (P<0.01). CONCLUSION: Our results suggest a correlation between IBS and DED. DED symptoms can cause further complications in patients with IBS, and should be considered in their management. However, further research is needed to establish a possible pathophysiologic association. |
format | Online Article Text |
id | pubmed-5049556 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hellenic Society of Gastroenterology |
record_format | MEDLINE/PubMed |
spelling | pubmed-50495562016-10-05 Irritable bowel syndrome might be associated with dry eye disease Asproudis, Ioannis Tsoumani, Anthoula T. Katsanos, Konstantinos H. Katsanos, Aristeidis H. Theopistos, Vasileios Paschidis, Konstantinos A. Tsianos, Epameinondas V. Christodoulou, Dimitrios Ann Gastroenterol Original Article BACKGROUND: A possible association between dry eye disease (DED) and irritable bowel syndrome (IBS) has been hypothesized based on the fact that they both share an inflammatory pathogenesis. METHODS: Ninety-five patients with IBS and 276 healthy controls were enrolled in the study. All patients answered a questionnaire regarding DED symptoms and had a complete ophthalmic examination. DED signs were evaluated using Schirmer’s 1 and tear break-up time (tBUT) tests in both groups. RESULTS: Female IBS participants presented significantly lower Schirmer’s test and tBUT (P=0.002 and P<0.001 respectively) than controls. Both diagnostic tests in male IBS patients were also significantly lower than in controls (P<0.001). 72% of IBS patients gave at least 3 positive answers to the questionnaire compared with 42% of the control group (P<0.01). CONCLUSION: Our results suggest a correlation between IBS and DED. DED symptoms can cause further complications in patients with IBS, and should be considered in their management. However, further research is needed to establish a possible pathophysiologic association. Hellenic Society of Gastroenterology 2016 2016-06-16 /pmc/articles/PMC5049556/ /pubmed/27708515 http://dx.doi.org/10.20524/aog.2016.0064 Text en Copyright: © Hellenic Society of Gastroenterology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Asproudis, Ioannis Tsoumani, Anthoula T. Katsanos, Konstantinos H. Katsanos, Aristeidis H. Theopistos, Vasileios Paschidis, Konstantinos A. Tsianos, Epameinondas V. Christodoulou, Dimitrios Irritable bowel syndrome might be associated with dry eye disease |
title | Irritable bowel syndrome might be associated with dry eye disease |
title_full | Irritable bowel syndrome might be associated with dry eye disease |
title_fullStr | Irritable bowel syndrome might be associated with dry eye disease |
title_full_unstemmed | Irritable bowel syndrome might be associated with dry eye disease |
title_short | Irritable bowel syndrome might be associated with dry eye disease |
title_sort | irritable bowel syndrome might be associated with dry eye disease |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049556/ https://www.ncbi.nlm.nih.gov/pubmed/27708515 http://dx.doi.org/10.20524/aog.2016.0064 |
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