A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease

Crimean-Congo Hemorrhagic Fever (CCHF) is a severe tick-borne disease, endemic in many countries in Africa, the Middle East, Eastern Europe and Asia. Between 15–70% of reported cases are fatal with no approved vaccine available. In the present study, the attenuated poxvirus vector, Modified Vaccinia...

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Autores principales: Dowall, SD, Buttigieg, KR, Findlay-Wilson, SJD, Rayner, E, Pearson, G, Miloszewska, A, Graham, VA, Carroll, MW, Hewson, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049717/
https://www.ncbi.nlm.nih.gov/pubmed/26309231
http://dx.doi.org/10.1080/21645515.2015.1078045
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author Dowall, SD
Buttigieg, KR
Findlay-Wilson, SJD
Rayner, E
Pearson, G
Miloszewska, A
Graham, VA
Carroll, MW
Hewson, R
author_facet Dowall, SD
Buttigieg, KR
Findlay-Wilson, SJD
Rayner, E
Pearson, G
Miloszewska, A
Graham, VA
Carroll, MW
Hewson, R
author_sort Dowall, SD
collection PubMed
description Crimean-Congo Hemorrhagic Fever (CCHF) is a severe tick-borne disease, endemic in many countries in Africa, the Middle East, Eastern Europe and Asia. Between 15–70% of reported cases are fatal with no approved vaccine available. In the present study, the attenuated poxvirus vector, Modified Vaccinia virus Ankara, was used to develop a recombinant candidate vaccine expressing the CCHF virus nucleoprotein. Cellular and humoral immunogenicity was confirmed in 2 mouse strains, including type I interferon receptor knockout mice, which are susceptible to CCHF disease. Despite the immune responses generated post-immunisation, the vaccine failed to protect animals from lethal disease in a challenge model.
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spelling pubmed-50497172016-10-12 A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease Dowall, SD Buttigieg, KR Findlay-Wilson, SJD Rayner, E Pearson, G Miloszewska, A Graham, VA Carroll, MW Hewson, R Hum Vaccin Immunother Research Papers Crimean-Congo Hemorrhagic Fever (CCHF) is a severe tick-borne disease, endemic in many countries in Africa, the Middle East, Eastern Europe and Asia. Between 15–70% of reported cases are fatal with no approved vaccine available. In the present study, the attenuated poxvirus vector, Modified Vaccinia virus Ankara, was used to develop a recombinant candidate vaccine expressing the CCHF virus nucleoprotein. Cellular and humoral immunogenicity was confirmed in 2 mouse strains, including type I interferon receptor knockout mice, which are susceptible to CCHF disease. Despite the immune responses generated post-immunisation, the vaccine failed to protect animals from lethal disease in a challenge model. Taylor & Francis 2015-08-26 /pmc/articles/PMC5049717/ /pubmed/26309231 http://dx.doi.org/10.1080/21645515.2015.1078045 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Research Papers
Dowall, SD
Buttigieg, KR
Findlay-Wilson, SJD
Rayner, E
Pearson, G
Miloszewska, A
Graham, VA
Carroll, MW
Hewson, R
A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease
title A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease
title_full A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease
title_fullStr A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease
title_full_unstemmed A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease
title_short A Crimean-Congo hemorrhagic fever (CCHF) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease
title_sort crimean-congo hemorrhagic fever (cchf) viral vaccine expressing nucleoprotein is immunogenic but fails to confer protection against lethal disease
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049717/
https://www.ncbi.nlm.nih.gov/pubmed/26309231
http://dx.doi.org/10.1080/21645515.2015.1078045
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