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The Non-Linear Child: Ontogeny, Isoniazid Concentration, and NAT2 Genotype Modulate Enzyme Reaction Kinetics and Metabolism

N-acetyltransferase 2 (NAT2) catalyzes the acetylation of isoniazid to N-acetylisoniazid. NAT2 polymorphism explains 88% of isoniazid clearance variability in adults. We examined the effects of clinical and genetic factors on Michaelis-Menten reaction kinetic constants of maximum velocity (V(max)) a...

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Detalles Bibliográficos
Autores principales:	Rogers, Zoe, Hiruy, Hiwot, Pasipanodya, Jotam G., Mbowane, Chris, Adamson, John, Ngotho, Lihle, Karim, Farina, Jeena, Prakash, Bishai, William, Gumbo, Tawanda
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049930/ https://www.ncbi.nlm.nih.gov/pubmed/27528266 http://dx.doi.org/10.1016/j.ebiom.2016.07.031

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