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A near atomic structure of the active human apoptosome

In response to cell death signals, an active apoptosome is assembled from Apaf-1 and procaspase-9 (pc-9). Here we report a near atomic structure of the active human apoptosome determined by cryo-electron microscopy. The resulting model gives insights into cytochrome c binding, nucleotide exchange an...

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Detalles Bibliográficos
Autores principales:	Cheng, Tat Cheung, Hong, Chuan, Akey, Ildikó V, Yuan, Shujun, Akey, Christopher W
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050015/ https://www.ncbi.nlm.nih.gov/pubmed/27697150 http://dx.doi.org/10.7554/eLife.17755

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