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Rac1-mediated membrane raft localization of PI3K/p110β is required for its activation by GPCRs or PTEN loss

We aimed to understand how spatial compartmentalization in the plasma membrane might contribute to the functions of the ubiquitous class IA phosphoinositide 3-kinase (PI3K) isoforms, p110α and p110β. We found that p110β localizes to membrane rafts in a Rac1-dependent manner. This localization potent...

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Detalles Bibliográficos
Autores principales:	Cizmecioglu, Onur, Ni, Jing, Xie, Shaozhen, Zhao, Jean J, Roberts, Thomas M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050018/ https://www.ncbi.nlm.nih.gov/pubmed/27700986 http://dx.doi.org/10.7554/eLife.17635

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