Cargando…

The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains

An expanded GGGGCC hexanucleotide in C9ORF72 (C9) is the most frequent known cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). It has been proposed that expanded transcripts adopt G-quadruplex (G-Q) structures and associate with proteins, but whether this occurs and con...

Descripción completa

Detalles Bibliográficos
Autores principales:	Conlon, Erin G, Lu, Lei, Sharma, Aarti, Yamazaki, Takashi, Tang, Timothy, Shneider, Neil A, Manley, James L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050020/ https://www.ncbi.nlm.nih.gov/pubmed/27623008 http://dx.doi.org/10.7554/eLife.17820

Ejemplares similares

Telomere Function and the G-Quadruplex Formation are Regulated by hnRNP U
por: Izumi, Hiroto, et al.
Publicado: (2019)

Tandem hnRNP A1 RNA recognition motifs act in concert to repress the splicing of survival motor neuron exon 7
por: Beusch, Irene, et al.
Publicado: (2017)

hnRNP A1 and hnRNP F Modulate the Alternative Splicing of Exon 11 of the Insulin Receptor Gene
por: Talukdar, Indrani, et al.
Publicado: (2011)

Paralogs hnRNP L and hnRNP LL Exhibit Overlapping but Distinct RNA Binding Constraints
por: Smith, Sarah A., et al.
Publicado: (2013)

Intronic Binding Sites for hnRNP A/B and hnRNP F/H Proteins Stimulate Pre-mRNA Splicing
por: Martinez-Contreras, Rebeca, et al.
Publicado: (2006)

HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA
por: Rahman, Mohammad Alinoor, et al.
Publicado: (2013)

HnRNP L represses cryptic exons
por: McClory, Sean P., et al.
Publicado: (2018)

HnRNP Pathologies in Frontotemporal Lobar Degeneration
por: Jiang, Xinwa, et al.
Publicado: (2023)

The Eµ-hnRNP K Murine Model of Lymphoma: Novel Insights into the Role of hnRNP K in B-Cell Malignancies
por: Malaney, Prerna, et al.
Publicado: (2021)

hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen–Glucose Deprivation in Hippocampal Neurons
por: Kim, Sung Wook, et al.
Publicado: (2021)

hnRNP A1 and hnRNP C associate with miR‐17 and miR‐18 in thyroid cancer cells
por: dos Santos, Maria Gabriela Pereira, et al.
Publicado: (2022)

Isolation of hnRNP complexes from Drosophila melanogaster
Publicado: (1992)

The hnRNP family: insights into their role in health and disease
por: Geuens, Thomas, et al.
Publicado: (2016)

Linking hnRNP Function to ALS and FTD Pathology
por: Purice, Maria D., et al.
Publicado: (2018)

An analysis of the role of HnRNP C dysregulation in cancers
por: Mo, Liyi, et al.
Publicado: (2022)

hnRNP A1 and secondary structure coordinate alternative splicing of Mag
por: Zearfoss, N. Ruth, et al.
Publicado: (2013)

G-Quadruplexes Formation by the C9orf72 Nucleotide Repeat Expansion d(GGGGCC)(n) and Conformation Regulation by Fangchinoline
por: Zhang, Yun, et al.
Publicado: (2023)

Characterization of the major hnRNP proteins from Drosophila melanogaster
Publicado: (1992)

Caspase-3 cleaves hnRNP K in erythroid differentiation
por: Naarmann-de Vries, I S, et al.
Publicado: (2013)

Stress-Induced Accumulation of HnRNP K into Stress Granules
por: Kim, Jayoung, et al.
Publicado: (2021)

Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism
por: Conlon, Erin G, et al.
Publicado: (2018)

TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency
por: Yamazaki, Takashi, et al.
Publicado: (2018)

Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia
por: Fratta, Pietro, et al.
Publicado: (2013)

DNA Replication Dynamics of the GGGGCC Repeat of the C9orf72 Gene
por: Thys, Ryan Griffin, et al.
Publicado: (2015)

Control of alternative splicing by forskolin through hnRNP K during neuronal differentiation
por: Cao, Wenguang, et al.
Publicado: (2012)

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution
por: König, Julian, et al.
Publicado: (2010)

A nuclear localization domain in the hnRNP A1 protein
Publicado: (1995)

Association of individual hnRNP proteins and snRNPs with nascent transcripts
Publicado: (1993)

AUF1/hnRNP D represses expression of VEGF in macrophages
por: Fellows, Abigail, et al.
Publicado: (2012)

hnRNP F Complexes with Tristetraprolin and Stimulates ARE-mRNA Decay
por: Reznik, Boris, et al.
Publicado: (2014)

hnRNP A1: The Swiss Army Knife of Gene Expression
por: Jean-Philippe, Jacques, et al.
Publicado: (2013)

Phosphorylation of hnRNP K controls cytosolic accumulation of TDP-43
por: White, Anthony, et al.
Publicado: (2013)

Identification and characterization of an hnRNP E1 translational silencing motif
por: Brown, Andrew S., et al.
Publicado: (2016)

The Novel Role of hnRNP UL1 in Human Cell Nucleoli
por: Cichocka, Marlena, et al.
Publicado: (2022)

HnRNP C, YB-1 and hnRNP L coordinately enhance skipping of human MUSK exon 10 to generate a Wnt-insensitive MuSK isoform
por: Nasrin, Farhana, et al.
Publicado: (2014)

hnRNP H/F drive RNA G-quadruplex-mediated translation linked to genomic instability and therapy resistance in glioblastoma
por: Herviou, Pauline, et al.
Publicado: (2020)

Srrm234, but not canonical SR and hnRNP proteins, drive inclusion of Dscam exon 9 variable exons
por: Ustaoglu, Pinar, et al.
Publicado: (2019)

The Role of Polypyrimidine Tract-Binding Proteins and Other hnRNP Proteins in Plant Splicing Regulation
por: Wachter, Andreas, et al.
Publicado: (2012)

Global identification of hnRNP A1 binding sites for SSO-based splicing modulation
por: Bruun, Gitte H., et al.
Publicado: (2016)

Suppression of HPV-16 late L1 5′-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs
por: Li, Xiaoze, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_9dbl1d7i84ugmbe7aqunjn4ujb