Vitamin D/Vitamin D Receptor Axis Regulates DNA Repair During Oncogene-Induced Senescence

Oncogenic Ras expression is associated with activation of the DNA damage response (DDR) pathway, as evidenced by elevated DNA damage, primarily DNA double-strand breaks (DSBs), and activation of DNA damage checkpoints, which in primary human cells leads to entry into senescence. DDR activation is vi...

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Detalles Bibliográficos
Autores principales: Graziano, Simona, Johnston, Rachel, Deng, Ou, Zhang, Junran, Gonzalo, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050051/
https://www.ncbi.nlm.nih.gov/pubmed/27041576
http://dx.doi.org/10.1038/onc.2016.77

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