Human dihydrofolate reductase influences the sensitivity of the malaria parasite Plasmodium falciparum to ketotifen – A cautionary tale in screening transgenic parasites

Ketotifen has recently been reported to inhibit the growth of both asexual and sexual malaria parasites. A parasite transporter, PfgABCG2, has been implicated in its mechanism of action. Human dihydrofolate reductase (hDHFR) is the most commonly used selectable marker to create transgenic Plasmodium...

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Detalles Bibliográficos
Autores principales: Tran, Phuong N., Tate, Cameron J., Ridgway, Melanie C., Saliba, Kevin J., Kirk, Kiaran, Maier, Alexander G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050295/
https://www.ncbi.nlm.nih.gov/pubmed/27705841
http://dx.doi.org/10.1016/j.ijpddr.2016.09.003

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