Long Noncoding RNA H19 in Digestive System Cancers: A Meta-Analysis of Its Association with Pathological Features

Long noncoding RNA (lncRNA) H19 has been reported to be upregulated in malignant digestive tumors, but its clinical relevance is not yet established. The meta-analysis was to investigate the association between H19 expression and pathological features of digestive system cancers. The databases of Pu...

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Detalles Bibliográficos
Autores principales: Lin, Yang, Xu, Lijian, Wei, Wei, Zhang, Xiaohui, Ying, Rongchao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050321/
https://www.ncbi.nlm.nih.gov/pubmed/27738631
http://dx.doi.org/10.1155/2016/4863609
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author Lin, Yang
Xu, Lijian
Wei, Wei
Zhang, Xiaohui
Ying, Rongchao
author_facet Lin, Yang
Xu, Lijian
Wei, Wei
Zhang, Xiaohui
Ying, Rongchao
author_sort Lin, Yang
collection PubMed
description Long noncoding RNA (lncRNA) H19 has been reported to be upregulated in malignant digestive tumors, but its clinical relevance is not yet established. The meta-analysis was to investigate the association between H19 expression and pathological features of digestive system cancers. The databases of PubMed, EMBase, Web of Science, CNKI, and WanFang were searched for the related studies. A total of 478 patients from 6 studies were finally included. The meta-analysis showed that the patient group of high H19 expression had a higher risk of poorly differentiated grade, deep tumor invasion (T2 stage or more), lymph node metastasis, and advanced TNM stage than the group of low H19 expression, although there was no difference between them in terms of distant metastasis. Therefore, the high expression of lncRNA H19 might predict poor oncological outcomes of patients with digestive system cancers.
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spelling pubmed-50503212016-10-13 Long Noncoding RNA H19 in Digestive System Cancers: A Meta-Analysis of Its Association with Pathological Features Lin, Yang Xu, Lijian Wei, Wei Zhang, Xiaohui Ying, Rongchao Biomed Res Int Review Article Long noncoding RNA (lncRNA) H19 has been reported to be upregulated in malignant digestive tumors, but its clinical relevance is not yet established. The meta-analysis was to investigate the association between H19 expression and pathological features of digestive system cancers. The databases of PubMed, EMBase, Web of Science, CNKI, and WanFang were searched for the related studies. A total of 478 patients from 6 studies were finally included. The meta-analysis showed that the patient group of high H19 expression had a higher risk of poorly differentiated grade, deep tumor invasion (T2 stage or more), lymph node metastasis, and advanced TNM stage than the group of low H19 expression, although there was no difference between them in terms of distant metastasis. Therefore, the high expression of lncRNA H19 might predict poor oncological outcomes of patients with digestive system cancers. Hindawi Publishing Corporation 2016 2016-09-21 /pmc/articles/PMC5050321/ /pubmed/27738631 http://dx.doi.org/10.1155/2016/4863609 Text en Copyright © 2016 Yang Lin et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lin, Yang
Xu, Lijian
Wei, Wei
Zhang, Xiaohui
Ying, Rongchao
Long Noncoding RNA H19 in Digestive System Cancers: A Meta-Analysis of Its Association with Pathological Features
title Long Noncoding RNA H19 in Digestive System Cancers: A Meta-Analysis of Its Association with Pathological Features
title_full Long Noncoding RNA H19 in Digestive System Cancers: A Meta-Analysis of Its Association with Pathological Features
title_fullStr Long Noncoding RNA H19 in Digestive System Cancers: A Meta-Analysis of Its Association with Pathological Features
title_full_unstemmed Long Noncoding RNA H19 in Digestive System Cancers: A Meta-Analysis of Its Association with Pathological Features
title_short Long Noncoding RNA H19 in Digestive System Cancers: A Meta-Analysis of Its Association with Pathological Features
title_sort long noncoding rna h19 in digestive system cancers: a meta-analysis of its association with pathological features
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050321/
https://www.ncbi.nlm.nih.gov/pubmed/27738631
http://dx.doi.org/10.1155/2016/4863609
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