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Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss

Recent studies on animal models have shown that noise exposure that does not lead to permanent threshold shift (PTS) can cause considerable damage around the synapses between inner hair cells (IHCs) and type-I afferent auditory nerve fibers (ANFs). Disruption of these synapses not only disables the...

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Autores principales: Shi, Lijuan, Chang, Ying, Li, Xiaowei, Aiken, Steve, Liu, Lijie, Wang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050381/
https://www.ncbi.nlm.nih.gov/pubmed/27738526
http://dx.doi.org/10.1155/2016/6143164
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author Shi, Lijuan
Chang, Ying
Li, Xiaowei
Aiken, Steve
Liu, Lijie
Wang, Jian
author_facet Shi, Lijuan
Chang, Ying
Li, Xiaowei
Aiken, Steve
Liu, Lijie
Wang, Jian
author_sort Shi, Lijuan
collection PubMed
description Recent studies on animal models have shown that noise exposure that does not lead to permanent threshold shift (PTS) can cause considerable damage around the synapses between inner hair cells (IHCs) and type-I afferent auditory nerve fibers (ANFs). Disruption of these synapses not only disables the innervated ANFs but also results in the slow degeneration of spiral ganglion neurons if the synapses are not reestablished. Such a loss of ANFs should result in signal coding deficits, which are exacerbated by the bias of the damage toward synapses connecting low-spontaneous-rate (SR) ANFs, which are known to be vital for signal coding in noisy background. As there is no PTS, these functional deficits cannot be detected using routine audiological evaluations and may be unknown to subjects who have them. Such functional deficits in hearing without changes in sensitivity are generally called “noise-induced hidden hearing loss (NIHHL).” Here, we provide a brief review to address several critical issues related to NIHHL: (1) the mechanism of noise induced synaptic damage, (2) reversibility of the synaptic damage, (3) the functional deficits as the nature of NIHHL in animal studies, (4) evidence of NIHHL in human subjects, and (5) peripheral and central contribution of NIHHL.
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spelling pubmed-50503812016-10-13 Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss Shi, Lijuan Chang, Ying Li, Xiaowei Aiken, Steve Liu, Lijie Wang, Jian Neural Plast Review Article Recent studies on animal models have shown that noise exposure that does not lead to permanent threshold shift (PTS) can cause considerable damage around the synapses between inner hair cells (IHCs) and type-I afferent auditory nerve fibers (ANFs). Disruption of these synapses not only disables the innervated ANFs but also results in the slow degeneration of spiral ganglion neurons if the synapses are not reestablished. Such a loss of ANFs should result in signal coding deficits, which are exacerbated by the bias of the damage toward synapses connecting low-spontaneous-rate (SR) ANFs, which are known to be vital for signal coding in noisy background. As there is no PTS, these functional deficits cannot be detected using routine audiological evaluations and may be unknown to subjects who have them. Such functional deficits in hearing without changes in sensitivity are generally called “noise-induced hidden hearing loss (NIHHL).” Here, we provide a brief review to address several critical issues related to NIHHL: (1) the mechanism of noise induced synaptic damage, (2) reversibility of the synaptic damage, (3) the functional deficits as the nature of NIHHL in animal studies, (4) evidence of NIHHL in human subjects, and (5) peripheral and central contribution of NIHHL. Hindawi Publishing Corporation 2016 2016-09-21 /pmc/articles/PMC5050381/ /pubmed/27738526 http://dx.doi.org/10.1155/2016/6143164 Text en Copyright © 2016 Lijuan Shi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shi, Lijuan
Chang, Ying
Li, Xiaowei
Aiken, Steve
Liu, Lijie
Wang, Jian
Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss
title Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss
title_full Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss
title_fullStr Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss
title_full_unstemmed Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss
title_short Cochlear Synaptopathy and Noise-Induced Hidden Hearing Loss
title_sort cochlear synaptopathy and noise-induced hidden hearing loss
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050381/
https://www.ncbi.nlm.nih.gov/pubmed/27738526
http://dx.doi.org/10.1155/2016/6143164
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