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Inflammatory markers and clinical characteristics for predicting persistent positivity of interferon gamma release assay in dialysis population
The interferon-gamma release assay (IGRA) is useful for diagnosing latent tuberculosis infection (LTBI), however the rate of negative conversion is high, especially in dialysis patients. Few studies have focused on predicting persistently positive patients who are at high risk of tuberculosis reacti...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050411/ https://www.ncbi.nlm.nih.gov/pubmed/27703202 http://dx.doi.org/10.1038/srep34577 |
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author | Shu, Chin-Chung Hsu, Chia-Lin Lee, Chih-Yuan Wu, Vin-Cent Yang, Feng-Jung Wang, Jann-Yuan Yu, Chong-Jen Lee, Li-Na |
author_facet | Shu, Chin-Chung Hsu, Chia-Lin Lee, Chih-Yuan Wu, Vin-Cent Yang, Feng-Jung Wang, Jann-Yuan Yu, Chong-Jen Lee, Li-Na |
author_sort | Shu, Chin-Chung |
collection | PubMed |
description | The interferon-gamma release assay (IGRA) is useful for diagnosing latent tuberculosis infection (LTBI), however the rate of negative conversion is high, especially in dialysis patients. Few studies have focused on predicting persistently positive patients who are at high risk of tuberculosis reactivation. We screened dialysis patients, and used QuantiFERON-TB Gold In-tube (QFT-GIT) to identify LTBI. Of the 157 participants who had initially positive QFT-GIT, 82 had persistently positivity and 75 had negative conversion. The persistently positive group were younger, more were current smokers, and had higher plasma level of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and QFT-GIT responses than the negative conversion group. Multivariate logistic regression for persistent positivity revealed that high plasma sTREM-1 and QFT-GIT response, young age and TB contact history were independent factors. Currently smoking had borderline significance. The area under the receiver operating characteristic curve using the multi-factor model was 0.878, higher than 0.821 by QFT-GIT response of 0.95 IU/ml. In conclusion, dialysis patients with persistent LTBI status may be associated with a young age, high plasma sTREM-1, strong QFT-GIT response, currently smoking, and TB contact history. If resources are limited, these five predictors can be used to prioritize QFT-GIT-positive dialysis patients for LTBI treatment. |
format | Online Article Text |
id | pubmed-5050411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50504112016-10-11 Inflammatory markers and clinical characteristics for predicting persistent positivity of interferon gamma release assay in dialysis population Shu, Chin-Chung Hsu, Chia-Lin Lee, Chih-Yuan Wu, Vin-Cent Yang, Feng-Jung Wang, Jann-Yuan Yu, Chong-Jen Lee, Li-Na Sci Rep Article The interferon-gamma release assay (IGRA) is useful for diagnosing latent tuberculosis infection (LTBI), however the rate of negative conversion is high, especially in dialysis patients. Few studies have focused on predicting persistently positive patients who are at high risk of tuberculosis reactivation. We screened dialysis patients, and used QuantiFERON-TB Gold In-tube (QFT-GIT) to identify LTBI. Of the 157 participants who had initially positive QFT-GIT, 82 had persistently positivity and 75 had negative conversion. The persistently positive group were younger, more were current smokers, and had higher plasma level of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and QFT-GIT responses than the negative conversion group. Multivariate logistic regression for persistent positivity revealed that high plasma sTREM-1 and QFT-GIT response, young age and TB contact history were independent factors. Currently smoking had borderline significance. The area under the receiver operating characteristic curve using the multi-factor model was 0.878, higher than 0.821 by QFT-GIT response of 0.95 IU/ml. In conclusion, dialysis patients with persistent LTBI status may be associated with a young age, high plasma sTREM-1, strong QFT-GIT response, currently smoking, and TB contact history. If resources are limited, these five predictors can be used to prioritize QFT-GIT-positive dialysis patients for LTBI treatment. Nature Publishing Group 2016-10-05 /pmc/articles/PMC5050411/ /pubmed/27703202 http://dx.doi.org/10.1038/srep34577 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Shu, Chin-Chung Hsu, Chia-Lin Lee, Chih-Yuan Wu, Vin-Cent Yang, Feng-Jung Wang, Jann-Yuan Yu, Chong-Jen Lee, Li-Na Inflammatory markers and clinical characteristics for predicting persistent positivity of interferon gamma release assay in dialysis population |
title | Inflammatory markers and clinical characteristics for predicting persistent positivity of interferon gamma release assay in dialysis population |
title_full | Inflammatory markers and clinical characteristics for predicting persistent positivity of interferon gamma release assay in dialysis population |
title_fullStr | Inflammatory markers and clinical characteristics for predicting persistent positivity of interferon gamma release assay in dialysis population |
title_full_unstemmed | Inflammatory markers and clinical characteristics for predicting persistent positivity of interferon gamma release assay in dialysis population |
title_short | Inflammatory markers and clinical characteristics for predicting persistent positivity of interferon gamma release assay in dialysis population |
title_sort | inflammatory markers and clinical characteristics for predicting persistent positivity of interferon gamma release assay in dialysis population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050411/ https://www.ncbi.nlm.nih.gov/pubmed/27703202 http://dx.doi.org/10.1038/srep34577 |
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