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Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk

Interleukin (IL) 16 plays a key role in inflammatory diseases as well as in tumorigenesis of osteosarcoma (OS). The aim of this study was to investigate the association of IL16 polymorphisms and plasma IL16 level with OS risk in a Chinese population. We genotyped IL16 rs4778889, rs11556218, and rs40...

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Autores principales: Tang, Yu-Jin, Wang, Jun-Li, Xie, Ke-Gong, Lan, Chang-Gong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050415/
https://www.ncbi.nlm.nih.gov/pubmed/27703190
http://dx.doi.org/10.1038/srep34607
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author Tang, Yu-Jin
Wang, Jun-Li
Xie, Ke-Gong
Lan, Chang-Gong
author_facet Tang, Yu-Jin
Wang, Jun-Li
Xie, Ke-Gong
Lan, Chang-Gong
author_sort Tang, Yu-Jin
collection PubMed
description Interleukin (IL) 16 plays a key role in inflammatory diseases as well as in tumorigenesis of osteosarcoma (OS). The aim of this study was to investigate the association of IL16 polymorphisms and plasma IL16 level with OS risk in a Chinese population. We genotyped IL16 rs4778889, rs11556218, and rs4072111 in 358 patients with OS and 402 controls using a polymerase chain reaction-restriction fragment length polymorphism assay. Plasma IL16 level was measured by enzyme-linked immunosorbent assay. Rs11556218 was associated with an increased risk of OS in heterozygote comparison (adjusted OR = 1.65, 95% CI, 1.23–2.21, P < 0.001), dominant model (adjusted OR = 1.66, 95% CI, 1.24–2.21, P < 0.001), and allele comparison (adjusted OR = 1.44, 95% CI, 1.14–1.81, P = 0.002). Moreover, rs11556218 TG/GG genotypes were associated with higher levels of IL16 as compared to TT genotype (P = 0.03). However, no significant association of rs4778889 and rs4072111 and OS was found. These findings suggest that rs11556218 TG/GG genotypes may be associated with increased susceptibility to OS, probably by increasing the production of IL16 level.
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spelling pubmed-50504152016-10-11 Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk Tang, Yu-Jin Wang, Jun-Li Xie, Ke-Gong Lan, Chang-Gong Sci Rep Article Interleukin (IL) 16 plays a key role in inflammatory diseases as well as in tumorigenesis of osteosarcoma (OS). The aim of this study was to investigate the association of IL16 polymorphisms and plasma IL16 level with OS risk in a Chinese population. We genotyped IL16 rs4778889, rs11556218, and rs4072111 in 358 patients with OS and 402 controls using a polymerase chain reaction-restriction fragment length polymorphism assay. Plasma IL16 level was measured by enzyme-linked immunosorbent assay. Rs11556218 was associated with an increased risk of OS in heterozygote comparison (adjusted OR = 1.65, 95% CI, 1.23–2.21, P < 0.001), dominant model (adjusted OR = 1.66, 95% CI, 1.24–2.21, P < 0.001), and allele comparison (adjusted OR = 1.44, 95% CI, 1.14–1.81, P = 0.002). Moreover, rs11556218 TG/GG genotypes were associated with higher levels of IL16 as compared to TT genotype (P = 0.03). However, no significant association of rs4778889 and rs4072111 and OS was found. These findings suggest that rs11556218 TG/GG genotypes may be associated with increased susceptibility to OS, probably by increasing the production of IL16 level. Nature Publishing Group 2016-10-05 /pmc/articles/PMC5050415/ /pubmed/27703190 http://dx.doi.org/10.1038/srep34607 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Tang, Yu-Jin
Wang, Jun-Li
Xie, Ke-Gong
Lan, Chang-Gong
Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk
title Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk
title_full Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk
title_fullStr Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk
title_full_unstemmed Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk
title_short Association of interleukin 16 gene polymorphisms and plasma IL16 level with osteosarcoma risk
title_sort association of interleukin 16 gene polymorphisms and plasma il16 level with osteosarcoma risk
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050415/
https://www.ncbi.nlm.nih.gov/pubmed/27703190
http://dx.doi.org/10.1038/srep34607
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