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Necrostatin-1 treatment inhibits osteocyte necroptosis and trabecular deterioration in ovariectomized rats

Estrogen (E2) deficiency has been associated with accelerated osteocyte apoptosis. Our previous study showed necroptosis accelerated the loss of osteocytes in E2 deficiency-induced osteoporosis in rats in addition to apoptosis, but the mechanism involved remains. Necroptosis is a caspase-independent...

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Detalles Bibliográficos
Autores principales: Cui, Hongwang, Zhu, Yongjun, Yang, Qiming, Zhao, Weikang, Zhang, Shiyang, Zhou, Ao, Jiang, Dianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050438/
https://www.ncbi.nlm.nih.gov/pubmed/27703177
http://dx.doi.org/10.1038/srep33803