Comparison of the Aerosol Stability of 2 Strains of Zaire ebolavirus From the 1976 and 2013 Outbreaks

The largest outbreak of Ebola virus disease began in Guéckédou, Guinea, West Africa, in December 2013 and rapidly spread to major population centers in 3 West African countries. Early reports in some scientific and public media speculated that the virus had evolved to more effectively transmit betwe...

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Autores principales: Fischer, Robert J., Bushmaker, Trenton, Judson, Seth, Munster, Vincent J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Ebola Outbreak in West Africa
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050463/
https://www.ncbi.nlm.nih.gov/pubmed/27503365
http://dx.doi.org/10.1093/infdis/jiw193
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author Fischer, Robert J.
Bushmaker, Trenton
Judson, Seth
Munster, Vincent J.
author_facet Fischer, Robert J.
Bushmaker, Trenton
Judson, Seth
Munster, Vincent J.
author_sort Fischer, Robert J.
collection PubMed
description The largest outbreak of Ebola virus disease began in Guéckédou, Guinea, West Africa, in December 2013 and rapidly spread to major population centers in 3 West African countries. Early reports in some scientific and public media speculated that the virus had evolved to more effectively transmit between humans. One route of transmission postulated was aerosol transmission, although there was little epidemiological evidence to support this claim. This study investigates the viability of 2 Zaire ebolavirus strains within aerosols at 22°C and 80% relative humidity over time. The results presented here indicate that there is no difference in virus stability between the 2 strains and that viable virus can be recovered from an aerosol 180 minutes after it is generated.
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spelling pubmed-50504632017-10-15 Comparison of the Aerosol Stability of 2 Strains of Zaire ebolavirus From the 1976 and 2013 Outbreaks Fischer, Robert J. Bushmaker, Trenton Judson, Seth Munster, Vincent J. J Infect Dis Ebola Outbreak in West Africa The largest outbreak of Ebola virus disease began in Guéckédou, Guinea, West Africa, in December 2013 and rapidly spread to major population centers in 3 West African countries. Early reports in some scientific and public media speculated that the virus had evolved to more effectively transmit between humans. One route of transmission postulated was aerosol transmission, although there was little epidemiological evidence to support this claim. This study investigates the viability of 2 Zaire ebolavirus strains within aerosols at 22°C and 80% relative humidity over time. The results presented here indicate that there is no difference in virus stability between the 2 strains and that viable virus can be recovered from an aerosol 180 minutes after it is generated. Oxford University Press 2016-10-15 2016-10-04 /pmc/articles/PMC5050463/ /pubmed/27503365 http://dx.doi.org/10.1093/infdis/jiw193 Text en Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US. This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.
spellingShingle Ebola Outbreak in West Africa
Fischer, Robert J.
Bushmaker, Trenton
Judson, Seth
Munster, Vincent J.
Comparison of the Aerosol Stability of 2 Strains of Zaire ebolavirus From the 1976 and 2013 Outbreaks
title Comparison of the Aerosol Stability of 2 Strains of Zaire ebolavirus From the 1976 and 2013 Outbreaks
title_full Comparison of the Aerosol Stability of 2 Strains of Zaire ebolavirus From the 1976 and 2013 Outbreaks
title_fullStr Comparison of the Aerosol Stability of 2 Strains of Zaire ebolavirus From the 1976 and 2013 Outbreaks
title_full_unstemmed Comparison of the Aerosol Stability of 2 Strains of Zaire ebolavirus From the 1976 and 2013 Outbreaks
title_short Comparison of the Aerosol Stability of 2 Strains of Zaire ebolavirus From the 1976 and 2013 Outbreaks
title_sort comparison of the aerosol stability of 2 strains of zaire ebolavirus from the 1976 and 2013 outbreaks
topic Ebola Outbreak in West Africa
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050463/
https://www.ncbi.nlm.nih.gov/pubmed/27503365
http://dx.doi.org/10.1093/infdis/jiw193
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