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New low-flux mixed matrix membranes that offer superior removal of protein-bound toxins from human plasma
Hemodialysis is a widely available and well-established treatment for patients with End Stage Renal Disease (ESRD). However, although life-sustaining, patient mortality rates are very high. Several recent studies corroborated the link between dialysis patients’ outcomes and elevated levels of protei...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050520/ https://www.ncbi.nlm.nih.gov/pubmed/27703258 http://dx.doi.org/10.1038/srep34429 |
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author | Pavlenko, Denys van Geffen, Esmée van Steenbergen, Mies J. Glorieux, Griet Vanholder, Raymond Gerritsen, Karin G. F. Stamatialis, Dimitrios |
author_facet | Pavlenko, Denys van Geffen, Esmée van Steenbergen, Mies J. Glorieux, Griet Vanholder, Raymond Gerritsen, Karin G. F. Stamatialis, Dimitrios |
author_sort | Pavlenko, Denys |
collection | PubMed |
description | Hemodialysis is a widely available and well-established treatment for patients with End Stage Renal Disease (ESRD). However, although life-sustaining, patient mortality rates are very high. Several recent studies corroborated the link between dialysis patients’ outcomes and elevated levels of protein-bound uremic toxins (PBUT) that are poorly removed by conventional hemodialysis. Therefore, new treatments are needed to improve their removal. Recently, our group showed that the combination of dialysis and adsorption on one membrane, the mixed matrix membrane (MMM), can effectively remove those toxins from human plasma. However, these first MMMs were rather large in diameter and their mass transport characteristics needed improvement before application in the clinical setting. Therefore, in this study we developed a new generation of MMMs that have a smaller diameter and optimized characteristics offering superior ability in removing the PBUT indoxyl sulfate (IS) and p-cresyl sulfate (pCS) in comparison to first generation MMMs (30 and 125% respectively), as well as, a commercial dialysis membrane (more than 100% better removal). |
format | Online Article Text |
id | pubmed-5050520 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-50505202016-10-11 New low-flux mixed matrix membranes that offer superior removal of protein-bound toxins from human plasma Pavlenko, Denys van Geffen, Esmée van Steenbergen, Mies J. Glorieux, Griet Vanholder, Raymond Gerritsen, Karin G. F. Stamatialis, Dimitrios Sci Rep Article Hemodialysis is a widely available and well-established treatment for patients with End Stage Renal Disease (ESRD). However, although life-sustaining, patient mortality rates are very high. Several recent studies corroborated the link between dialysis patients’ outcomes and elevated levels of protein-bound uremic toxins (PBUT) that are poorly removed by conventional hemodialysis. Therefore, new treatments are needed to improve their removal. Recently, our group showed that the combination of dialysis and adsorption on one membrane, the mixed matrix membrane (MMM), can effectively remove those toxins from human plasma. However, these first MMMs were rather large in diameter and their mass transport characteristics needed improvement before application in the clinical setting. Therefore, in this study we developed a new generation of MMMs that have a smaller diameter and optimized characteristics offering superior ability in removing the PBUT indoxyl sulfate (IS) and p-cresyl sulfate (pCS) in comparison to first generation MMMs (30 and 125% respectively), as well as, a commercial dialysis membrane (more than 100% better removal). Nature Publishing Group 2016-10-05 /pmc/articles/PMC5050520/ /pubmed/27703258 http://dx.doi.org/10.1038/srep34429 Text en Copyright © 2016, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Pavlenko, Denys van Geffen, Esmée van Steenbergen, Mies J. Glorieux, Griet Vanholder, Raymond Gerritsen, Karin G. F. Stamatialis, Dimitrios New low-flux mixed matrix membranes that offer superior removal of protein-bound toxins from human plasma |
title | New low-flux mixed matrix membranes that offer superior removal of protein-bound toxins from human plasma |
title_full | New low-flux mixed matrix membranes that offer superior removal of protein-bound toxins from human plasma |
title_fullStr | New low-flux mixed matrix membranes that offer superior removal of protein-bound toxins from human plasma |
title_full_unstemmed | New low-flux mixed matrix membranes that offer superior removal of protein-bound toxins from human plasma |
title_short | New low-flux mixed matrix membranes that offer superior removal of protein-bound toxins from human plasma |
title_sort | new low-flux mixed matrix membranes that offer superior removal of protein-bound toxins from human plasma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050520/ https://www.ncbi.nlm.nih.gov/pubmed/27703258 http://dx.doi.org/10.1038/srep34429 |
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