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Impaired Ca(2+) release contributes to muscle weakness in a rat model of critical illness myopathy

BACKGROUND: Critical illness myopathy is an acquired skeletal muscle disorder with severe myosin loss and muscle weakness frequently seen in intensive care unit (ICU) patients. It is unknown if impaired excitation-contraction coupling contributes to the muscle weakness. METHODS: We used a unique ICU...

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Detalles Bibliográficos
Autores principales: Llano-Diez, Monica, Cheng, Arthur J., Jonsson, William, Ivarsson, Niklas, Westerblad, Håkan, Sun, Vic, Cacciani, Nicola, Larsson, Lars, Bruton, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5050561/
https://www.ncbi.nlm.nih.gov/pubmed/27510990
http://dx.doi.org/10.1186/s13054-016-1417-z