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Gastroduodenal Changes Two Years After Eradication of Helicobacter pylori in a Population-Based Cohort

BACKGROUND: The main cause of chronic gastritis is Helicobacter pylori (H. pylori) infection. Some individuals with H. pylori-related chronic gastritis develop atrophy of the gastric mucosa, a risk factor for gastric neoplasia. When H. pylori-associated gastritis is encountered, it is important to b...

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Autores principales: Redeen, Stefan, Petersson, Fredrik, Kechagias, Stergios, Rehfeld, Jens, Borch, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051142/
https://www.ncbi.nlm.nih.gov/pubmed/27785292
http://dx.doi.org/10.14740/gr646w
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author Redeen, Stefan
Petersson, Fredrik
Kechagias, Stergios
Rehfeld, Jens
Borch, Kurt
author_facet Redeen, Stefan
Petersson, Fredrik
Kechagias, Stergios
Rehfeld, Jens
Borch, Kurt
author_sort Redeen, Stefan
collection PubMed
description BACKGROUND: The main cause of chronic gastritis is Helicobacter pylori (H. pylori) infection. Some individuals with H. pylori-related chronic gastritis develop atrophy of the gastric mucosa, a risk factor for gastric neoplasia. When H. pylori-associated gastritis is encountered, it is important to be aware of its natural history and reversibility of associated histopathological and hormonal changes. METHODS: A sample of 501 volunteers from the general population in the municipality of Linkoping, Sweden, was examined with esophago-gastro-duodenoscopy (EGD) with biopsy. Blood samples were collected in the fasting state and the subjects answered a questionnaire concerning lifestyle factors, medications and disease history. At a primary follow-up examination, after 8 years, 314 participants were re-examined and those infected with H. pylori received eradication. Two years after successful eradication therapy, 82 participants attended re-examination with EGD and blood sampling, as in the previous examinations. RESULTS: In this prospective cohort study of a sample of volunteers from the general population, all of the 82 participants had chronic gastritis with at least one positive H. pylori test before eradication therapy. During follow-up, non-steroid-inflammatory-drug (NSAID) use had decreased significantly (P = 0.007, McNemar). The H. pylori serology was still positive in 79/82 subjects (P = 0.007, McNemar). The basal gastrin and cholecystokinin (CCK) concentrations both had decreased (P < 0.001 for both, Wilcoxon), whereas the P-somatostatin had increased (P < 0.001, Wilcoxon). Symptoms included in the self-administered symptom questionnaire concerned the last 3 months showed no big difference at all. The inflammation had decreased in both antrum (before 2/38/42/0 and after 60/22/0/0, P < 0.0001) and corpus (before 3/54/22/3 and after 58/23/1/0, P < 0.0001). Changes in the inflammatory activity had decreased significantly in both the antrum (P < 0.001) and the corpus (P < 0.001). Intestinal metaplasia was without changes. Regarding the duodenal bulb, the inflammation decreased. CONCLUSIONS: Being aware of the natural history of chronic gastritis, even beyond eradication of H. pylori, is important because of the associations to gastric neoplasia and ulcer disease. The blood mirror of gastroduodenal parameters showed decreased values, except for somatostatin that increased and a symptomatology with no significant changes although, morphologically determined, both inflammation and atrophy had decreased.
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spelling pubmed-50511422016-10-26 Gastroduodenal Changes Two Years After Eradication of Helicobacter pylori in a Population-Based Cohort Redeen, Stefan Petersson, Fredrik Kechagias, Stergios Rehfeld, Jens Borch, Kurt Gastroenterology Res Original Article BACKGROUND: The main cause of chronic gastritis is Helicobacter pylori (H. pylori) infection. Some individuals with H. pylori-related chronic gastritis develop atrophy of the gastric mucosa, a risk factor for gastric neoplasia. When H. pylori-associated gastritis is encountered, it is important to be aware of its natural history and reversibility of associated histopathological and hormonal changes. METHODS: A sample of 501 volunteers from the general population in the municipality of Linkoping, Sweden, was examined with esophago-gastro-duodenoscopy (EGD) with biopsy. Blood samples were collected in the fasting state and the subjects answered a questionnaire concerning lifestyle factors, medications and disease history. At a primary follow-up examination, after 8 years, 314 participants were re-examined and those infected with H. pylori received eradication. Two years after successful eradication therapy, 82 participants attended re-examination with EGD and blood sampling, as in the previous examinations. RESULTS: In this prospective cohort study of a sample of volunteers from the general population, all of the 82 participants had chronic gastritis with at least one positive H. pylori test before eradication therapy. During follow-up, non-steroid-inflammatory-drug (NSAID) use had decreased significantly (P = 0.007, McNemar). The H. pylori serology was still positive in 79/82 subjects (P = 0.007, McNemar). The basal gastrin and cholecystokinin (CCK) concentrations both had decreased (P < 0.001 for both, Wilcoxon), whereas the P-somatostatin had increased (P < 0.001, Wilcoxon). Symptoms included in the self-administered symptom questionnaire concerned the last 3 months showed no big difference at all. The inflammation had decreased in both antrum (before 2/38/42/0 and after 60/22/0/0, P < 0.0001) and corpus (before 3/54/22/3 and after 58/23/1/0, P < 0.0001). Changes in the inflammatory activity had decreased significantly in both the antrum (P < 0.001) and the corpus (P < 0.001). Intestinal metaplasia was without changes. Regarding the duodenal bulb, the inflammation decreased. CONCLUSIONS: Being aware of the natural history of chronic gastritis, even beyond eradication of H. pylori, is important because of the associations to gastric neoplasia and ulcer disease. The blood mirror of gastroduodenal parameters showed decreased values, except for somatostatin that increased and a symptomatology with no significant changes although, morphologically determined, both inflammation and atrophy had decreased. Elmer Press 2015-04 2015-04-03 /pmc/articles/PMC5051142/ /pubmed/27785292 http://dx.doi.org/10.14740/gr646w Text en Copyright 2015, Redeen et al. http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Redeen, Stefan
Petersson, Fredrik
Kechagias, Stergios
Rehfeld, Jens
Borch, Kurt
Gastroduodenal Changes Two Years After Eradication of Helicobacter pylori in a Population-Based Cohort
title Gastroduodenal Changes Two Years After Eradication of Helicobacter pylori in a Population-Based Cohort
title_full Gastroduodenal Changes Two Years After Eradication of Helicobacter pylori in a Population-Based Cohort
title_fullStr Gastroduodenal Changes Two Years After Eradication of Helicobacter pylori in a Population-Based Cohort
title_full_unstemmed Gastroduodenal Changes Two Years After Eradication of Helicobacter pylori in a Population-Based Cohort
title_short Gastroduodenal Changes Two Years After Eradication of Helicobacter pylori in a Population-Based Cohort
title_sort gastroduodenal changes two years after eradication of helicobacter pylori in a population-based cohort
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051142/
https://www.ncbi.nlm.nih.gov/pubmed/27785292
http://dx.doi.org/10.14740/gr646w
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