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Pigment Epithelium-derived Factor and Matrix Metalloproteinase-9 in Liver Cirrhosis
BACKGROUND/AIM: The aim of this study was to assess the role of serum pigment epithelium-derived factor (PEDF) and matrix metalloproteinase-9 (MMP-9) in progression of liver cirrhosis and development of hepatocellular carcinoma (HCC). PATIENTS AND METHODS: Serum levels of PEDF and MMP-9 were tested...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051222/ https://www.ncbi.nlm.nih.gov/pubmed/27748324 http://dx.doi.org/10.4103/1319-3767.191143 |
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author | Kozłowska, Joanna Mikuła, Tomasz Suchacz, Magdalena Jabłnońska, Joanna Stańczak, Wojciech Cianciara, Janusz Wiercińska-Drapało, Alicja |
author_facet | Kozłowska, Joanna Mikuła, Tomasz Suchacz, Magdalena Jabłnońska, Joanna Stańczak, Wojciech Cianciara, Janusz Wiercińska-Drapało, Alicja |
author_sort | Kozłowska, Joanna |
collection | PubMed |
description | BACKGROUND/AIM: The aim of this study was to assess the role of serum pigment epithelium-derived factor (PEDF) and matrix metalloproteinase-9 (MMP-9) in progression of liver cirrhosis and development of hepatocellular carcinoma (HCC). PATIENTS AND METHODS: Serum levels of PEDF and MMP-9 were tested in 212 patients with liver cirrhosis and in a control group of 30 healthy volunteers. HCC was diagnosed in 45 of the 212 patients studied (21%). RESULTS: Serum PEDF and MMP-9 were higher in the study group than that in the control group (P < 0.001). In patients with alcoholic or mixed (alcoholic and viral hepatitis-related) cirrhosis, serum PEDF was higher than that in other patients (13970.2 ± 13406.9 ng/ml vs. 8563.5 ± 9602.7 ng/ml, P = 0.008). In patients with viral hepatitis-related cirrhosis, significantly higher PEDF levels were recorded in those with HCC (13429.1 ± 12045.8) than that in patients without HCC (6660.1 ± 7927.1; P = 0.04). There was a trend for higher serum MMP-9 in patients with HCC (5778.7 ± 12426.6 vs. 1389.8 ± 1944.7 in those without HCC; P = 0.07). Significant negative correlation between serum MMP-9 and serum alpha-fetoprotein in patients with HCC was observed (r = −0.54; P = 0.04). CONCLUSION: Serum PEDF and MMP-9 could be auxiliary markers in diagnosis of HCC, especially in patients with low alpha-fetoprotein level. Alcohol consumption can affect serum PEDF. |
format | Online Article Text |
id | pubmed-5051222 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-50512222016-10-07 Pigment Epithelium-derived Factor and Matrix Metalloproteinase-9 in Liver Cirrhosis Kozłowska, Joanna Mikuła, Tomasz Suchacz, Magdalena Jabłnońska, Joanna Stańczak, Wojciech Cianciara, Janusz Wiercińska-Drapało, Alicja Saudi J Gastroenterol Original Article BACKGROUND/AIM: The aim of this study was to assess the role of serum pigment epithelium-derived factor (PEDF) and matrix metalloproteinase-9 (MMP-9) in progression of liver cirrhosis and development of hepatocellular carcinoma (HCC). PATIENTS AND METHODS: Serum levels of PEDF and MMP-9 were tested in 212 patients with liver cirrhosis and in a control group of 30 healthy volunteers. HCC was diagnosed in 45 of the 212 patients studied (21%). RESULTS: Serum PEDF and MMP-9 were higher in the study group than that in the control group (P < 0.001). In patients with alcoholic or mixed (alcoholic and viral hepatitis-related) cirrhosis, serum PEDF was higher than that in other patients (13970.2 ± 13406.9 ng/ml vs. 8563.5 ± 9602.7 ng/ml, P = 0.008). In patients with viral hepatitis-related cirrhosis, significantly higher PEDF levels were recorded in those with HCC (13429.1 ± 12045.8) than that in patients without HCC (6660.1 ± 7927.1; P = 0.04). There was a trend for higher serum MMP-9 in patients with HCC (5778.7 ± 12426.6 vs. 1389.8 ± 1944.7 in those without HCC; P = 0.07). Significant negative correlation between serum MMP-9 and serum alpha-fetoprotein in patients with HCC was observed (r = −0.54; P = 0.04). CONCLUSION: Serum PEDF and MMP-9 could be auxiliary markers in diagnosis of HCC, especially in patients with low alpha-fetoprotein level. Alcohol consumption can affect serum PEDF. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5051222/ /pubmed/27748324 http://dx.doi.org/10.4103/1319-3767.191143 Text en Copyright: © 2016 Saudi Journal of Gastroenterology (Official journal of The Saudi Gastroenterology Association) http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Kozłowska, Joanna Mikuła, Tomasz Suchacz, Magdalena Jabłnońska, Joanna Stańczak, Wojciech Cianciara, Janusz Wiercińska-Drapało, Alicja Pigment Epithelium-derived Factor and Matrix Metalloproteinase-9 in Liver Cirrhosis |
title | Pigment Epithelium-derived Factor and Matrix Metalloproteinase-9 in Liver Cirrhosis |
title_full | Pigment Epithelium-derived Factor and Matrix Metalloproteinase-9 in Liver Cirrhosis |
title_fullStr | Pigment Epithelium-derived Factor and Matrix Metalloproteinase-9 in Liver Cirrhosis |
title_full_unstemmed | Pigment Epithelium-derived Factor and Matrix Metalloproteinase-9 in Liver Cirrhosis |
title_short | Pigment Epithelium-derived Factor and Matrix Metalloproteinase-9 in Liver Cirrhosis |
title_sort | pigment epithelium-derived factor and matrix metalloproteinase-9 in liver cirrhosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051222/ https://www.ncbi.nlm.nih.gov/pubmed/27748324 http://dx.doi.org/10.4103/1319-3767.191143 |
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