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Prospective comorbidity-matched study of Parkinson's disease and risk of mortality among women

BACKGROUND: Individuals with Parkinson's disease (PD) may have an increased risk of overall mortality compared to the general population. Women may have lower mortality rates from PD than men; however, studies among women on the effect of PD on mortality have been limited and may not have adequ...

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Autores principales: Winter, Anke C, Rist, Pamela M, Buring, Julie E, Kurth, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051400/
https://www.ncbi.nlm.nih.gov/pubmed/27670518
http://dx.doi.org/10.1136/bmjopen-2016-011888
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author Winter, Anke C
Rist, Pamela M
Buring, Julie E
Kurth, Tobias
author_facet Winter, Anke C
Rist, Pamela M
Buring, Julie E
Kurth, Tobias
author_sort Winter, Anke C
collection PubMed
description BACKGROUND: Individuals with Parkinson's disease (PD) may have an increased risk of overall mortality compared to the general population. Women may have lower mortality rates from PD than men; however, studies among women on the effect of PD on mortality have been limited and may not have adequately controlled for confounding by comorbidities. METHODS: We conducted a matched cohort study among participants in the Women's Health Study. 396 incident PD cases were identified through self-report. Each PD case was matched by age to a comparator who was alive and had the same modified Charlson comorbidity score as the PD case. The PD cases and matched comparators were followed for all-cause mortality. Cox proportional hazards models adjusted for age at the index date, smoking, alcohol consumption, exercise and body mass index were used to determine the association between PD and mortality. RESULTS: During a median of 6.2 years of follow-up, 72 women died (47 PD cases and 25 comparators). The multivariable-adjusted HR for mortality was 2.60 (95% CI 1.56 to 4.32). CONCLUSIONS: PD was associated with more than a twofold increased risk of all-cause mortality among women. Results are similar to those observed among men.
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spelling pubmed-50514002016-10-17 Prospective comorbidity-matched study of Parkinson's disease and risk of mortality among women Winter, Anke C Rist, Pamela M Buring, Julie E Kurth, Tobias BMJ Open Epidemiology BACKGROUND: Individuals with Parkinson's disease (PD) may have an increased risk of overall mortality compared to the general population. Women may have lower mortality rates from PD than men; however, studies among women on the effect of PD on mortality have been limited and may not have adequately controlled for confounding by comorbidities. METHODS: We conducted a matched cohort study among participants in the Women's Health Study. 396 incident PD cases were identified through self-report. Each PD case was matched by age to a comparator who was alive and had the same modified Charlson comorbidity score as the PD case. The PD cases and matched comparators were followed for all-cause mortality. Cox proportional hazards models adjusted for age at the index date, smoking, alcohol consumption, exercise and body mass index were used to determine the association between PD and mortality. RESULTS: During a median of 6.2 years of follow-up, 72 women died (47 PD cases and 25 comparators). The multivariable-adjusted HR for mortality was 2.60 (95% CI 1.56 to 4.32). CONCLUSIONS: PD was associated with more than a twofold increased risk of all-cause mortality among women. Results are similar to those observed among men. BMJ Publishing Group 2016-09-23 /pmc/articles/PMC5051400/ /pubmed/27670518 http://dx.doi.org/10.1136/bmjopen-2016-011888 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/ This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/4.0/
spellingShingle Epidemiology
Winter, Anke C
Rist, Pamela M
Buring, Julie E
Kurth, Tobias
Prospective comorbidity-matched study of Parkinson's disease and risk of mortality among women
title Prospective comorbidity-matched study of Parkinson's disease and risk of mortality among women
title_full Prospective comorbidity-matched study of Parkinson's disease and risk of mortality among women
title_fullStr Prospective comorbidity-matched study of Parkinson's disease and risk of mortality among women
title_full_unstemmed Prospective comorbidity-matched study of Parkinson's disease and risk of mortality among women
title_short Prospective comorbidity-matched study of Parkinson's disease and risk of mortality among women
title_sort prospective comorbidity-matched study of parkinson's disease and risk of mortality among women
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051400/
https://www.ncbi.nlm.nih.gov/pubmed/27670518
http://dx.doi.org/10.1136/bmjopen-2016-011888
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