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Clinical outcomes of adverse cardiovascular events in patients with acute dapsone poisoning
OBJECTIVE: Adverse cardiovascular events (ACVEs) account for a large proportion of the morbidities and mortalities associated with drug overdose emergencies. However, there are no published reports regarding outcomes of ACVEs associated with acute dapsone poisoning. Here, the authors retrospectively...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Emergency Medicine
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051622/ https://www.ncbi.nlm.nih.gov/pubmed/27752614 http://dx.doi.org/10.15441/ceem.15.088 |
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author | Kang, Kyung Sik Kim, Hyung Il Kim, Oh Hyun Cha, Kyoung Chul Kim, Hyun Lee, Kang Hyun Hwang, Sung Oh Cha, Yong Sung |
author_facet | Kang, Kyung Sik Kim, Hyung Il Kim, Oh Hyun Cha, Kyoung Chul Kim, Hyun Lee, Kang Hyun Hwang, Sung Oh Cha, Yong Sung |
author_sort | Kang, Kyung Sik |
collection | PubMed |
description | OBJECTIVE: Adverse cardiovascular events (ACVEs) account for a large proportion of the morbidities and mortalities associated with drug overdose emergencies. However, there are no published reports regarding outcomes of ACVEs associated with acute dapsone poisoning. Here, the authors retrospectively analyzed ACVEs reported within 48 hours of treatment in patients with acute dapsone poisoning and assessed the significance of ACVEs as early predictors of mortality. METHODS: Sixty-one consecutive cases of acute dapsone poisoning that were diagnosed and treated at a regional emergency center between 2006 and 2014 were included in the study. An ACVE was defined as myocardial injury, shock, ventricular dysrhythmia, cardiac arrest, or any combination of these occurring within the first 48 hours of treatment for acute dapsone poisoning. RESULTS: Nineteen patients (31.1%) had evidence of myocardial injury (elevation of serum troponin-I level or electrocardiography signs of ischemia) after dapsone overdose, and there were a total of 19 ACVEs (31.1%), including one case of shock (1.6%). Fourteen patients (23.0%) died from pneumonia or multiple organ failure, and the incidence of ACVEs was significantly higher among non-survivors than among survivors (64.3% vs. 21.3%, P=0.006). ACVE was a significant predictor of mortality (odds ratio, 5.690; 95% confidence interval, 1.428 to 22.675; P=0.014). CONCLUSION: The incidence of ACVE was significantly higher among patients who died after acute dapsone poisoning. ACVE is a significant predictor of mortality after dapsone overdose, and evidence of ACVE should be carefully sought in these patients. |
format | Online Article Text |
id | pubmed-5051622 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Society of Emergency Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-50516222016-10-17 Clinical outcomes of adverse cardiovascular events in patients with acute dapsone poisoning Kang, Kyung Sik Kim, Hyung Il Kim, Oh Hyun Cha, Kyoung Chul Kim, Hyun Lee, Kang Hyun Hwang, Sung Oh Cha, Yong Sung Clin Exp Emerg Med Original Article OBJECTIVE: Adverse cardiovascular events (ACVEs) account for a large proportion of the morbidities and mortalities associated with drug overdose emergencies. However, there are no published reports regarding outcomes of ACVEs associated with acute dapsone poisoning. Here, the authors retrospectively analyzed ACVEs reported within 48 hours of treatment in patients with acute dapsone poisoning and assessed the significance of ACVEs as early predictors of mortality. METHODS: Sixty-one consecutive cases of acute dapsone poisoning that were diagnosed and treated at a regional emergency center between 2006 and 2014 were included in the study. An ACVE was defined as myocardial injury, shock, ventricular dysrhythmia, cardiac arrest, or any combination of these occurring within the first 48 hours of treatment for acute dapsone poisoning. RESULTS: Nineteen patients (31.1%) had evidence of myocardial injury (elevation of serum troponin-I level or electrocardiography signs of ischemia) after dapsone overdose, and there were a total of 19 ACVEs (31.1%), including one case of shock (1.6%). Fourteen patients (23.0%) died from pneumonia or multiple organ failure, and the incidence of ACVEs was significantly higher among non-survivors than among survivors (64.3% vs. 21.3%, P=0.006). ACVE was a significant predictor of mortality (odds ratio, 5.690; 95% confidence interval, 1.428 to 22.675; P=0.014). CONCLUSION: The incidence of ACVE was significantly higher among patients who died after acute dapsone poisoning. ACVE is a significant predictor of mortality after dapsone overdose, and evidence of ACVE should be carefully sought in these patients. The Korean Society of Emergency Medicine 2016-03-31 /pmc/articles/PMC5051622/ /pubmed/27752614 http://dx.doi.org/10.15441/ceem.15.088 Text en Copyright © 2016 The Korean Society of Emergency Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kang, Kyung Sik Kim, Hyung Il Kim, Oh Hyun Cha, Kyoung Chul Kim, Hyun Lee, Kang Hyun Hwang, Sung Oh Cha, Yong Sung Clinical outcomes of adverse cardiovascular events in patients with acute dapsone poisoning |
title | Clinical outcomes of adverse cardiovascular events in patients with acute dapsone poisoning |
title_full | Clinical outcomes of adverse cardiovascular events in patients with acute dapsone poisoning |
title_fullStr | Clinical outcomes of adverse cardiovascular events in patients with acute dapsone poisoning |
title_full_unstemmed | Clinical outcomes of adverse cardiovascular events in patients with acute dapsone poisoning |
title_short | Clinical outcomes of adverse cardiovascular events in patients with acute dapsone poisoning |
title_sort | clinical outcomes of adverse cardiovascular events in patients with acute dapsone poisoning |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5051622/ https://www.ncbi.nlm.nih.gov/pubmed/27752614 http://dx.doi.org/10.15441/ceem.15.088 |
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