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Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice
Correlates of value are routinely observed in the prefrontal cortex (PFC) during reward-guided decision making. In previous work (Hunt et al., 2015), we argued that PFC correlates of chosen value are a consequence of varying rates of a dynamical evidence accumulation process. Yet within PFC, there i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052031/ https://www.ncbi.nlm.nih.gov/pubmed/27705742 http://dx.doi.org/10.7554/eLife.18937 |
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author | Cavanagh, Sean E Wallis, Joni D Kennerley, Steven W Hunt, Laurence T |
author_facet | Cavanagh, Sean E Wallis, Joni D Kennerley, Steven W Hunt, Laurence T |
author_sort | Cavanagh, Sean E |
collection | PubMed |
description | Correlates of value are routinely observed in the prefrontal cortex (PFC) during reward-guided decision making. In previous work (Hunt et al., 2015), we argued that PFC correlates of chosen value are a consequence of varying rates of a dynamical evidence accumulation process. Yet within PFC, there is substantial variability in chosen value correlates across individual neurons. Here we show that this variability is explained by neurons having different temporal receptive fields of integration, indexed by examining neuronal spike rate autocorrelation structure whilst at rest. We find that neurons with protracted resting temporal receptive fields exhibit stronger chosen value correlates during choice. Within orbitofrontal cortex, these neurons also sustain coding of chosen value from choice through the delivery of reward, providing a potential neural mechanism for maintaining predictions and updating stored values during learning. These findings reveal that within PFC, variability in temporal specialisation across neurons predicts involvement in specific decision-making computations. DOI: http://dx.doi.org/10.7554/eLife.18937.001 |
format | Online Article Text |
id | pubmed-5052031 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-50520312016-10-06 Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice Cavanagh, Sean E Wallis, Joni D Kennerley, Steven W Hunt, Laurence T eLife Neuroscience Correlates of value are routinely observed in the prefrontal cortex (PFC) during reward-guided decision making. In previous work (Hunt et al., 2015), we argued that PFC correlates of chosen value are a consequence of varying rates of a dynamical evidence accumulation process. Yet within PFC, there is substantial variability in chosen value correlates across individual neurons. Here we show that this variability is explained by neurons having different temporal receptive fields of integration, indexed by examining neuronal spike rate autocorrelation structure whilst at rest. We find that neurons with protracted resting temporal receptive fields exhibit stronger chosen value correlates during choice. Within orbitofrontal cortex, these neurons also sustain coding of chosen value from choice through the delivery of reward, providing a potential neural mechanism for maintaining predictions and updating stored values during learning. These findings reveal that within PFC, variability in temporal specialisation across neurons predicts involvement in specific decision-making computations. DOI: http://dx.doi.org/10.7554/eLife.18937.001 eLife Sciences Publications, Ltd 2016-10-05 /pmc/articles/PMC5052031/ /pubmed/27705742 http://dx.doi.org/10.7554/eLife.18937 Text en © 2016, Cavanagh et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Cavanagh, Sean E Wallis, Joni D Kennerley, Steven W Hunt, Laurence T Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice |
title | Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice |
title_full | Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice |
title_fullStr | Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice |
title_full_unstemmed | Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice |
title_short | Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice |
title_sort | autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052031/ https://www.ncbi.nlm.nih.gov/pubmed/27705742 http://dx.doi.org/10.7554/eLife.18937 |
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