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Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice

Correlates of value are routinely observed in the prefrontal cortex (PFC) during reward-guided decision making. In previous work (Hunt et al., 2015), we argued that PFC correlates of chosen value are a consequence of varying rates of a dynamical evidence accumulation process. Yet within PFC, there i...

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Detalles Bibliográficos
Autores principales: Cavanagh, Sean E, Wallis, Joni D, Kennerley, Steven W, Hunt, Laurence T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052031/
https://www.ncbi.nlm.nih.gov/pubmed/27705742
http://dx.doi.org/10.7554/eLife.18937
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author Cavanagh, Sean E
Wallis, Joni D
Kennerley, Steven W
Hunt, Laurence T
author_facet Cavanagh, Sean E
Wallis, Joni D
Kennerley, Steven W
Hunt, Laurence T
author_sort Cavanagh, Sean E
collection PubMed
description Correlates of value are routinely observed in the prefrontal cortex (PFC) during reward-guided decision making. In previous work (Hunt et al., 2015), we argued that PFC correlates of chosen value are a consequence of varying rates of a dynamical evidence accumulation process. Yet within PFC, there is substantial variability in chosen value correlates across individual neurons. Here we show that this variability is explained by neurons having different temporal receptive fields of integration, indexed by examining neuronal spike rate autocorrelation structure whilst at rest. We find that neurons with protracted resting temporal receptive fields exhibit stronger chosen value correlates during choice. Within orbitofrontal cortex, these neurons also sustain coding of chosen value from choice through the delivery of reward, providing a potential neural mechanism for maintaining predictions and updating stored values during learning. These findings reveal that within PFC, variability in temporal specialisation across neurons predicts involvement in specific decision-making computations. DOI: http://dx.doi.org/10.7554/eLife.18937.001
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spelling pubmed-50520312016-10-06 Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice Cavanagh, Sean E Wallis, Joni D Kennerley, Steven W Hunt, Laurence T eLife Neuroscience Correlates of value are routinely observed in the prefrontal cortex (PFC) during reward-guided decision making. In previous work (Hunt et al., 2015), we argued that PFC correlates of chosen value are a consequence of varying rates of a dynamical evidence accumulation process. Yet within PFC, there is substantial variability in chosen value correlates across individual neurons. Here we show that this variability is explained by neurons having different temporal receptive fields of integration, indexed by examining neuronal spike rate autocorrelation structure whilst at rest. We find that neurons with protracted resting temporal receptive fields exhibit stronger chosen value correlates during choice. Within orbitofrontal cortex, these neurons also sustain coding of chosen value from choice through the delivery of reward, providing a potential neural mechanism for maintaining predictions and updating stored values during learning. These findings reveal that within PFC, variability in temporal specialisation across neurons predicts involvement in specific decision-making computations. DOI: http://dx.doi.org/10.7554/eLife.18937.001 eLife Sciences Publications, Ltd 2016-10-05 /pmc/articles/PMC5052031/ /pubmed/27705742 http://dx.doi.org/10.7554/eLife.18937 Text en © 2016, Cavanagh et al http://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Cavanagh, Sean E
Wallis, Joni D
Kennerley, Steven W
Hunt, Laurence T
Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice
title Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice
title_full Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice
title_fullStr Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice
title_full_unstemmed Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice
title_short Autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice
title_sort autocorrelation structure at rest predicts value correlates of single neurons during reward-guided choice
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052031/
https://www.ncbi.nlm.nih.gov/pubmed/27705742
http://dx.doi.org/10.7554/eLife.18937
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