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Gene discovery by chemical mutagenesis and whole-genome sequencing in Dictyostelium

Whole-genome sequencing is a useful approach for identification of chemical-induced lesions, but previous applications involved tedious genetic mapping to pinpoint the causative mutations. We propose that saturation mutagenesis under low mutagenic loads, followed by whole-genome sequencing, should a...

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Detalles Bibliográficos
Autores principales:	Li, Cheng-Lin Frank, Santhanam, Balaji, Webb, Amanda Nicole, Zupan, Blaž, Shaulsky, Gad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2016
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5052037/ https://www.ncbi.nlm.nih.gov/pubmed/27307293 http://dx.doi.org/10.1101/gr.205682.116

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